BRIDGING THE GAP BETWEEN NEUROIMAGING AND NEURONAL PHYSIOLOGY
Despite the fact that blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) studies have become ubiquitous and are of ever increasing importance for clinical and basic neurosciences, the fundamental relationships between BOLD and the underlying neuronal physiology are...
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Society for Stereology and Quantitative Image Analysis
2011-05-01
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| Series: | Image Analysis and Stereology |
| Subjects: | |
| Online Access: | http://www.ias-iss.org/ojs/IAS/article/view/700 |
| _version_ | 1818890865530109952 |
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| author | Dae-Shik Kim Kamil Ugurbil |
| author_facet | Dae-Shik Kim Kamil Ugurbil |
| author_sort | Dae-Shik Kim |
| collection | DOAJ |
| description | Despite the fact that blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) studies have become ubiquitous and are of ever increasing importance for clinical and basic neurosciences, the fundamental relationships between BOLD and the underlying neuronal physiology are not understood. This raises severe concerns about the validity of BOLD contrast per se, and the conceptual frameworks currently employed in interpreting cognitive neuroimaging data. In order to expand the explanatory power of functional MRI data, several crucial questions will have to be addressed. The two most important questions are: First, what is the ultimate spatial resolution of fMRI?, secondly, what is the "neural correlate" of functional MRI? This article attempts to compile a series of results from our and other laboratories, suggesting that both the questions of "spatial specificity" and "neural correlate" might be within the reach of a tentative solution, thus finally bridging the gap between functional neuroimaging and neuronal physiology. |
| first_indexed | 2024-12-19T17:31:42Z |
| format | Article |
| id | doaj.art-d887ae7e8bc542199b598d3dcb492772 |
| institution | Directory Open Access Journal |
| issn | 1580-3139 1854-5165 |
| language | English |
| last_indexed | 2024-12-19T17:31:42Z |
| publishDate | 2011-05-01 |
| publisher | Slovenian Society for Stereology and Quantitative Image Analysis |
| record_format | Article |
| series | Image Analysis and Stereology |
| spelling | doaj.art-d887ae7e8bc542199b598d3dcb4927722022-12-21T20:12:26ZengSlovenian Society for Stereology and Quantitative Image AnalysisImage Analysis and Stereology1580-31391854-51652011-05-012129710510.5566/ias.v21.p97-105672BRIDGING THE GAP BETWEEN NEUROIMAGING AND NEURONAL PHYSIOLOGYDae-Shik KimKamil UgurbilDespite the fact that blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) studies have become ubiquitous and are of ever increasing importance for clinical and basic neurosciences, the fundamental relationships between BOLD and the underlying neuronal physiology are not understood. This raises severe concerns about the validity of BOLD contrast per se, and the conceptual frameworks currently employed in interpreting cognitive neuroimaging data. In order to expand the explanatory power of functional MRI data, several crucial questions will have to be addressed. The two most important questions are: First, what is the ultimate spatial resolution of fMRI?, secondly, what is the "neural correlate" of functional MRI? This article attempts to compile a series of results from our and other laboratories, suggesting that both the questions of "spatial specificity" and "neural correlate" might be within the reach of a tentative solution, thus finally bridging the gap between functional neuroimaging and neuronal physiology.http://www.ias-iss.org/ojs/IAS/article/view/700BOLD specificitycat visual cortexfMRIneural correlate |
| spellingShingle | Dae-Shik Kim Kamil Ugurbil BRIDGING THE GAP BETWEEN NEUROIMAGING AND NEURONAL PHYSIOLOGY Image Analysis and Stereology BOLD specificity cat visual cortex fMRI neural correlate |
| title | BRIDGING THE GAP BETWEEN NEUROIMAGING AND NEURONAL PHYSIOLOGY |
| title_full | BRIDGING THE GAP BETWEEN NEUROIMAGING AND NEURONAL PHYSIOLOGY |
| title_fullStr | BRIDGING THE GAP BETWEEN NEUROIMAGING AND NEURONAL PHYSIOLOGY |
| title_full_unstemmed | BRIDGING THE GAP BETWEEN NEUROIMAGING AND NEURONAL PHYSIOLOGY |
| title_short | BRIDGING THE GAP BETWEEN NEUROIMAGING AND NEURONAL PHYSIOLOGY |
| title_sort | bridging the gap between neuroimaging and neuronal physiology |
| topic | BOLD specificity cat visual cortex fMRI neural correlate |
| url | http://www.ias-iss.org/ojs/IAS/article/view/700 |
| work_keys_str_mv | AT daeshikkim bridgingthegapbetweenneuroimagingandneuronalphysiology AT kamilugurbil bridgingthegapbetweenneuroimagingandneuronalphysiology |