Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association
Introduction: Polyglandular syndrome is characterized by the association of autoimmune, organ-specific, endocrine and non-endocrine diseases. Objective: To present a case of polyglandular syndrome type III (b) accompanied by pernicious anemia and autoimmune thyroiditis. Method: Report the clinical c...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2015-01-01
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| Series: | GE: Portuguese Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2341454514001185 |
| _version_ | 1828836556633276416 |
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| author | Arthur Wagner Pimentel de Sousa Vanessa Maia da Silva Priscilla Alencar Fernandes Daniel Uchôa Araújo Gilmar Mamede de Carvalho Erick José de Morais Villar Mônica Souza de Miranda-Henriques |
| author_facet | Arthur Wagner Pimentel de Sousa Vanessa Maia da Silva Priscilla Alencar Fernandes Daniel Uchôa Araújo Gilmar Mamede de Carvalho Erick José de Morais Villar Mônica Souza de Miranda-Henriques |
| author_sort | Arthur Wagner Pimentel de Sousa |
| collection | DOAJ |
| description | Introduction: Polyglandular syndrome is characterized by the association of autoimmune, organ-specific, endocrine and non-endocrine diseases.
Objective: To present a case of polyglandular syndrome type III (b) accompanied by pernicious anemia and autoimmune thyroiditis.
Method: Report the clinical case of a young patient that developed progressive and disabling peripheral neuropathy framework, triggered by vitamin B12 deficiency.
Discussion: It was proven that atrophic gastritis with positive intrinsic anti-factor was responsible for the framework of pernicious anemia, which in turn dangerously reduced the serum levels of vitamin B12, leading to myelopathy. There was a progressive neurological improvement after parenteral cyanocobalamin replacement, keeping the patient at ambulatory, under maintenance therapy.
Conclusion: The importance of suspecting on polyglandular syndrome in the presence of autoimmune frameworks is important, especially those involving diabetes, thyroiditis, atrophic gastritis, pernicious anemia, vitiligo, among others. |
| first_indexed | 2024-12-12T18:23:33Z |
| format | Article |
| id | doaj.art-d889e986e5e8498cacd8f1a82c54d8c1 |
| institution | Directory Open Access Journal |
| issn | 2341-4545 |
| language | English |
| last_indexed | 2024-12-12T18:23:33Z |
| publishDate | 2015-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | GE: Portuguese Journal of Gastroenterology |
| spelling | doaj.art-d889e986e5e8498cacd8f1a82c54d8c12022-12-22T00:16:05ZengKarger PublishersGE: Portuguese Journal of Gastroenterology2341-45452015-01-01221151810.1016/j.jpge.2014.08.001Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual AssociationArthur Wagner Pimentel de Sousa0Vanessa Maia da Silva1Priscilla Alencar Fernandes2Daniel Uchôa Araújo3Gilmar Mamede de Carvalho4Erick José de Morais Villar5Mônica Souza de Miranda-Henriques6Universidade Federal da Paraíba, Paraíba, BrazilUniversidade Federal da Paraíba, Paraíba, BrazilUniversidade Federal da Paraíba, Paraíba, BrazilUniversidade Federal da Paraíba, Paraíba, BrazilUniversidade Federal da Paraíba, Paraíba, BrazilLauro Wanderley University Hospital, Universidade Federal da Paraíba, Paraíba, BrazilInternal Medicine Department, Universidade Federal da Paraíba, Paraíba, BrazilIntroduction: Polyglandular syndrome is characterized by the association of autoimmune, organ-specific, endocrine and non-endocrine diseases. Objective: To present a case of polyglandular syndrome type III (b) accompanied by pernicious anemia and autoimmune thyroiditis. Method: Report the clinical case of a young patient that developed progressive and disabling peripheral neuropathy framework, triggered by vitamin B12 deficiency. Discussion: It was proven that atrophic gastritis with positive intrinsic anti-factor was responsible for the framework of pernicious anemia, which in turn dangerously reduced the serum levels of vitamin B12, leading to myelopathy. There was a progressive neurological improvement after parenteral cyanocobalamin replacement, keeping the patient at ambulatory, under maintenance therapy. Conclusion: The importance of suspecting on polyglandular syndrome in the presence of autoimmune frameworks is important, especially those involving diabetes, thyroiditis, atrophic gastritis, pernicious anemia, vitiligo, among others.http://www.sciencedirect.com/science/article/pii/S2341454514001185Gastritis, AtrophicAnemia, PerniciousThyroiditis, AutoimmuneVitamin B 12 DeficiencySpinal Cord Diseases |
| spellingShingle | Arthur Wagner Pimentel de Sousa Vanessa Maia da Silva Priscilla Alencar Fernandes Daniel Uchôa Araújo Gilmar Mamede de Carvalho Erick José de Morais Villar Mônica Souza de Miranda-Henriques Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association GE: Portuguese Journal of Gastroenterology Gastritis, Atrophic Anemia, Pernicious Thyroiditis, Autoimmune Vitamin B 12 Deficiency Spinal Cord Diseases |
| title | Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association |
| title_full | Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association |
| title_fullStr | Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association |
| title_full_unstemmed | Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association |
| title_short | Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association |
| title_sort | polyglandular syndrome type iii and severe peripheral neuropathy an unusual association |
| topic | Gastritis, Atrophic Anemia, Pernicious Thyroiditis, Autoimmune Vitamin B 12 Deficiency Spinal Cord Diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2341454514001185 |
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