Quorum Sensing Inhibition by Marine Bacteria
Antibiotic resistance has been increasingly reported for a wide variety of bacteria of clinical significance. This widespread problem constitutes one of the greatest challenges of the twenty-first century. Faced with this issue, clinicians and researchers have been persuaded to design novel strategi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/17/7/427 |
| _version_ | 1811279007397707776 |
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| author | Anabela Borges Manuel Simões |
| author_facet | Anabela Borges Manuel Simões |
| author_sort | Anabela Borges |
| collection | DOAJ |
| description | Antibiotic resistance has been increasingly reported for a wide variety of bacteria of clinical significance. This widespread problem constitutes one of the greatest challenges of the twenty-first century. Faced with this issue, clinicians and researchers have been persuaded to design novel strategies in order to try to control pathogenic bacteria. Therefore, the discovery and elucidation of the mechanisms underlying bacterial pathogenesis and intercellular communication have opened new perspectives for the development of alternative approaches. Antipathogenic and/or antivirulence therapies based on the interruption of quorum sensing pathways are one of several such promising strategies aimed at disarming rather than at eradicating bacterial pathogens during the course of colonization and infection. This review describes mechanisms of bacterial communication involved in biofilm formation. An overview of the potential of marine bacteria and their bioactive components as QS inhibitors is further provided. |
| first_indexed | 2024-04-13T00:47:04Z |
| format | Article |
| id | doaj.art-d889e9b07059429a8c0faa3a5ae97cde |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T00:47:04Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-d889e9b07059429a8c0faa3a5ae97cde2022-12-22T03:09:59ZengMDPI AGMarine Drugs1660-33972019-07-0117742710.3390/md17070427md17070427Quorum Sensing Inhibition by Marine BacteriaAnabela Borges0Manuel Simões1LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, PortugalLEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, PortugalAntibiotic resistance has been increasingly reported for a wide variety of bacteria of clinical significance. This widespread problem constitutes one of the greatest challenges of the twenty-first century. Faced with this issue, clinicians and researchers have been persuaded to design novel strategies in order to try to control pathogenic bacteria. Therefore, the discovery and elucidation of the mechanisms underlying bacterial pathogenesis and intercellular communication have opened new perspectives for the development of alternative approaches. Antipathogenic and/or antivirulence therapies based on the interruption of quorum sensing pathways are one of several such promising strategies aimed at disarming rather than at eradicating bacterial pathogens during the course of colonization and infection. This review describes mechanisms of bacterial communication involved in biofilm formation. An overview of the potential of marine bacteria and their bioactive components as QS inhibitors is further provided.https://www.mdpi.com/1660-3397/17/7/427antimicrobial resistanceantipathogenic and antivirulencequorum sensingquorum quenchingmarine bacteriaselective pressure |
| spellingShingle | Anabela Borges Manuel Simões Quorum Sensing Inhibition by Marine Bacteria Marine Drugs antimicrobial resistance antipathogenic and antivirulence quorum sensing quorum quenching marine bacteria selective pressure |
| title | Quorum Sensing Inhibition by Marine Bacteria |
| title_full | Quorum Sensing Inhibition by Marine Bacteria |
| title_fullStr | Quorum Sensing Inhibition by Marine Bacteria |
| title_full_unstemmed | Quorum Sensing Inhibition by Marine Bacteria |
| title_short | Quorum Sensing Inhibition by Marine Bacteria |
| title_sort | quorum sensing inhibition by marine bacteria |
| topic | antimicrobial resistance antipathogenic and antivirulence quorum sensing quorum quenching marine bacteria selective pressure |
| url | https://www.mdpi.com/1660-3397/17/7/427 |
| work_keys_str_mv | AT anabelaborges quorumsensinginhibitionbymarinebacteria AT manuelsimoes quorumsensinginhibitionbymarinebacteria |