Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome
Background Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. Objectives To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-03-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.14670 |
| _version_ | 1811182091767906304 |
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| author | M.‐F. Roy G.P.S. Kwong J. Lambert S. Massie S. Lockhart |
| author_facet | M.‐F. Roy G.P.S. Kwong J. Lambert S. Massie S. Lockhart |
| author_sort | M.‐F. Roy |
| collection | DOAJ |
| description | Background Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. Objectives To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome. Animals A total of 479 consecutive adult horse emergency admissions to a private primary referral practice. Methods Prospective observational study. All adult horses admitted for emergency treatment over the study period were included. Multivariate logistic regression and stepwise model selection were used. Results Each of the 4 SIRS criteria was associated with outcome in this population. Thirty‐one percent of emergency cases had 2 or more abnormal SIRS criteria on admission and were defined as SIRS cases. SIRS was associated with increased odds of death (odds ratio [OR] = 8.22; 95% CI, 4.61–15.18; P < .001), an effect mainly found for acute gastrointestinal cases. SIRS cases were assigned a SIRS score of 2, 3, or 4, according to the number of abnormal SIRS criteria fulfilled on admission, and SIRS3 and SIRS4 cases had increased odds of death compared to SIRS2 cases (OR = 4.45; 95% CI, 1.78–11.15; P = .002). A model of severe SIRS including the SIRS score, blood lactate concentration, and color of the mucous membranes best predicted outcome in this population of horses. Conclusions and Clinical Importance Systemic inflammatory response syndrome is associated with an increased risk of death in adult horses presenting with acute gastrointestinal illnesses. The model of severe SIRS proposed in this study could be used to assess the status and prognosis of adult equine emergency admissions. |
| first_indexed | 2024-04-11T09:26:14Z |
| format | Article |
| id | doaj.art-d88a9df24e2f4b4096ca3a793c309bc1 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T09:26:14Z |
| publishDate | 2017-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-d88a9df24e2f4b4096ca3a793c309bc12022-12-22T04:32:01ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762017-03-0131258259210.1111/jvim.14670Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response SyndromeM.‐F. Roy0G.P.S. Kwong1J. Lambert2S. Massie3S. Lockhart4Department of Veterinary Clinical and Diagnostic Sciences Faculty of Veterinary Medicine University of Calgary Calgary AB CanadaFaculty of Veterinary Medicine University of Calgary Calgary AB CanadaDepartment of Veterinary Clinical and Diagnostic Sciences Faculty of Veterinary Medicine University of Calgary Calgary AB CanadaDepartment of Veterinary Clinical and Diagnostic Sciences Faculty of Veterinary Medicine University of Calgary Calgary AB CanadaMoore Equine Veterinary Center North Clinic Rocky View County AB CanadaBackground Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. Objectives To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome. Animals A total of 479 consecutive adult horse emergency admissions to a private primary referral practice. Methods Prospective observational study. All adult horses admitted for emergency treatment over the study period were included. Multivariate logistic regression and stepwise model selection were used. Results Each of the 4 SIRS criteria was associated with outcome in this population. Thirty‐one percent of emergency cases had 2 or more abnormal SIRS criteria on admission and were defined as SIRS cases. SIRS was associated with increased odds of death (odds ratio [OR] = 8.22; 95% CI, 4.61–15.18; P < .001), an effect mainly found for acute gastrointestinal cases. SIRS cases were assigned a SIRS score of 2, 3, or 4, according to the number of abnormal SIRS criteria fulfilled on admission, and SIRS3 and SIRS4 cases had increased odds of death compared to SIRS2 cases (OR = 4.45; 95% CI, 1.78–11.15; P = .002). A model of severe SIRS including the SIRS score, blood lactate concentration, and color of the mucous membranes best predicted outcome in this population of horses. Conclusions and Clinical Importance Systemic inflammatory response syndrome is associated with an increased risk of death in adult horses presenting with acute gastrointestinal illnesses. The model of severe SIRS proposed in this study could be used to assess the status and prognosis of adult equine emergency admissions.https://doi.org/10.1111/jvim.14670EquineLactateMucous membranesOutcome |
| spellingShingle | M.‐F. Roy G.P.S. Kwong J. Lambert S. Massie S. Lockhart Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome Journal of Veterinary Internal Medicine Equine Lactate Mucous membranes Outcome |
| title | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
| title_full | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
| title_fullStr | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
| title_full_unstemmed | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
| title_short | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
| title_sort | prognostic value and development of a scoring system in horses with systemic inflammatory response syndrome |
| topic | Equine Lactate Mucous membranes Outcome |
| url | https://doi.org/10.1111/jvim.14670 |
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