Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint
<p>Abstract</p> <p>Background</p> <p>Little is known of how the toxicity of nanoparticles is affected by the incorporation in complex matrices. We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO<sub>2</sub>), pure or em...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-02-01
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| Series: | Particle and Fibre Toxicology |
| Subjects: | |
| Online Access: | http://www.particleandfibretoxicology.com/content/9/1/4 |
| _version_ | 1818234528047562752 |
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| author | Saber Anne Jacobsen Nicklas Mortensen Alicia Szarek Józef Jackson Petra Madsen Anne Jensen Keld Koponen Ismo K Brunborg Gunnar Gützkow Kristine Vogel Ulla Wallin Håkan |
| author_facet | Saber Anne Jacobsen Nicklas Mortensen Alicia Szarek Józef Jackson Petra Madsen Anne Jensen Keld Koponen Ismo K Brunborg Gunnar Gützkow Kristine Vogel Ulla Wallin Håkan |
| author_sort | Saber Anne |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Little is known of how the toxicity of nanoparticles is affected by the incorporation in complex matrices. We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO<sub>2</sub>), pure or embedded in a paint matrix. We also compared the effects of the same paint with and without NanoTiO<sub>2</sub>.</p> <p>Methods</p> <p>Mice received a single intratracheal instillation of 18, 54 and 162 μg of NanoTiO<sub>2 </sub>or 54, 162 and 486 μg of the sanding dust from paint with and without NanoTiO<sub>2</sub>. DNA damage in broncheoalveolar lavage cells and liver, lung inflammation and liver histology were evaluated 1, 3 and 28 days after intratracheal instillation. Printex 90 was included as positive control.</p> <p>Results</p> <p>There was no additive effect of adding NanoTiO<sub>2 </sub>to paints: Therefore the toxicity of NanoTiO<sub>2 </sub>was reduced by inclusion into a paint matrix. NanoTiO<sub>2 </sub>induced inflammation in mice with severity similar to Printex 90. The inflammatory response of NanoTiO<sub>2 </sub>and Printex 90 correlated with the instilled surface area. None of the materials, except of Printex 90, induced DNA damage in lung lining fluid cells. The highest dose of NanoTiO<sub>2 </sub>caused DNA damage in hepatic tissue 1 day after intratracheal instillation. Exposure of mice to the dust from paints with and without TiO<sub>2 </sub>was not associated with hepatic histopathological changes. Exposure to NanoTiO<sub>2 </sub>or to Printex 90 caused slight histopathological changes in the liver in some of the mice at different time points.</p> <p>Conclusions</p> <p>Pulmonary inflammation and DNA damage and hepatic histopathology were not changed in mice instilled with sanding dust from NanoTiO<sub>2 </sub>paint compared to paint without NanoTiO<sub>2</sub>. However, pure NanoTiO<sub>2 </sub>caused greater inflammation than NanoTiO<sub>2 </sub>embedded in the paint matrix.</p> |
| first_indexed | 2024-12-12T11:39:30Z |
| format | Article |
| id | doaj.art-d88ae735d0684c74a75ce69f5ab141e5 |
| institution | Directory Open Access Journal |
| issn | 1743-8977 |
| language | English |
| last_indexed | 2024-12-12T11:39:30Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Particle and Fibre Toxicology |
| spelling | doaj.art-d88ae735d0684c74a75ce69f5ab141e52022-12-22T00:25:35ZengBMCParticle and Fibre Toxicology1743-89772012-02-0191410.1186/1743-8977-9-4Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paintSaber AnneJacobsen NicklasMortensen AliciaSzarek JózefJackson PetraMadsen AnneJensen KeldKoponen Ismo KBrunborg GunnarGützkow KristineVogel UllaWallin Håkan<p>Abstract</p> <p>Background</p> <p>Little is known of how the toxicity of nanoparticles is affected by the incorporation in complex matrices. We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO<sub>2</sub>), pure or embedded in a paint matrix. We also compared the effects of the same paint with and without NanoTiO<sub>2</sub>.</p> <p>Methods</p> <p>Mice received a single intratracheal instillation of 18, 54 and 162 μg of NanoTiO<sub>2 </sub>or 54, 162 and 486 μg of the sanding dust from paint with and without NanoTiO<sub>2</sub>. DNA damage in broncheoalveolar lavage cells and liver, lung inflammation and liver histology were evaluated 1, 3 and 28 days after intratracheal instillation. Printex 90 was included as positive control.</p> <p>Results</p> <p>There was no additive effect of adding NanoTiO<sub>2 </sub>to paints: Therefore the toxicity of NanoTiO<sub>2 </sub>was reduced by inclusion into a paint matrix. NanoTiO<sub>2 </sub>induced inflammation in mice with severity similar to Printex 90. The inflammatory response of NanoTiO<sub>2 </sub>and Printex 90 correlated with the instilled surface area. None of the materials, except of Printex 90, induced DNA damage in lung lining fluid cells. The highest dose of NanoTiO<sub>2 </sub>caused DNA damage in hepatic tissue 1 day after intratracheal instillation. Exposure of mice to the dust from paints with and without TiO<sub>2 </sub>was not associated with hepatic histopathological changes. Exposure to NanoTiO<sub>2 </sub>or to Printex 90 caused slight histopathological changes in the liver in some of the mice at different time points.</p> <p>Conclusions</p> <p>Pulmonary inflammation and DNA damage and hepatic histopathology were not changed in mice instilled with sanding dust from NanoTiO<sub>2 </sub>paint compared to paint without NanoTiO<sub>2</sub>. However, pure NanoTiO<sub>2 </sub>caused greater inflammation than NanoTiO<sub>2 </sub>embedded in the paint matrix.</p>http://www.particleandfibretoxicology.com/content/9/1/4NanoparticlesNano titanium dioxideUV-Titan L181sanding dustspaint matrixinflammationDNA damageliver histology |
| spellingShingle | Saber Anne Jacobsen Nicklas Mortensen Alicia Szarek Józef Jackson Petra Madsen Anne Jensen Keld Koponen Ismo K Brunborg Gunnar Gützkow Kristine Vogel Ulla Wallin Håkan Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint Particle and Fibre Toxicology Nanoparticles Nano titanium dioxide UV-Titan L181 sanding dusts paint matrix inflammation DNA damage liver histology |
| title | Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint |
| title_full | Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint |
| title_fullStr | Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint |
| title_full_unstemmed | Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint |
| title_short | Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint |
| title_sort | nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint |
| topic | Nanoparticles Nano titanium dioxide UV-Titan L181 sanding dusts paint matrix inflammation DNA damage liver histology |
| url | http://www.particleandfibretoxicology.com/content/9/1/4 |
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