Recombinant Human Clusterin Seals Damage to the Ocular Surface Barrier in a Mouse Model of Ophthalmic Preservative-Induced Epitheliopathy

Recombinant Human Clusterin Seals Damage to the Ocular Surface Barrier in a Mouse Model of Ophthalmic Preservative-Induced Epitheliopathy

There is a significant unmet need for therapeutics to treat ocular surface barrier damage, also called epitheliopathy, due to dry eye and related diseases. We recently reported that the natural tear glycoprotein CLU (clusterin), a molecular chaperone and matrix metalloproteinase inhibitor, seals and...

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Bibliographic Details
Main Authors: Shravan K. Chintala, Jinhong Pan, Sandeep Satapathy, Rebecca Condruti, Zixuan Hao, Pei-wen Liu, Christian F. O’Conner, Joseph T. Barr, Mark R. Wilson, Shinwu Jeong, M. Elizabeth Fini
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
clusterin
dry eye
ocular surface
epitheliopathy
molecular chaperone
matrix metalloproteinase inhibitor
Online Access:https://www.mdpi.com/1422-0067/24/2/981

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