Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazole
Background and objective: Compounds having imine or azomethine (–C=N–) functional group are known as Schiff bases. Schiff bases compounds are found to be an active pharmacophore for the design and development of various bioactive lead compounds. In this study, several new Schiff base compounds have...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hawler Medical University
2019-08-01
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| Series: | Zanco Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://zjms.hmu.edu.krd/index.php/zjms/article/view/677/578 |
| _version_ | 1819053978113015808 |
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| author | Sarbast Muhammed Ahmed Kezhal M. Salih Hiwa Omer Ahmad Zanko H. Jawhar Dashti H. Hamad |
| author_facet | Sarbast Muhammed Ahmed Kezhal M. Salih Hiwa Omer Ahmad Zanko H. Jawhar Dashti H. Hamad |
| author_sort | Sarbast Muhammed Ahmed |
| collection | DOAJ |
| description | Background and objective: Compounds having imine or azomethine (–C=N–) functional group are known as Schiff bases. Schiff bases compounds are found to be an active pharmacophore for the design and development of various bioactive lead compounds. In this study, several new Schiff base compounds have been synthesized and characterized.
Methods: Williamson ether synthesis process has been used to synthesize -alkyloxy and substituted benzyloxy of benzaldehyde. Differently substituted ether benzaldehydes used to react with 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one in one hand and 1H-benzo[d]imidazol-2-amine on the other hand to produce Schiff base compounds.
Results: Synthesized ether derivative compounds (3a-e) were converted to new series of Schiff bases (4a-e and 5a-e) by condensation of equal molar amounts of compounds (3a-e) with different heterocyclic amines dissolved in absolute ethanol. All synthesized compounds were confirmed by (IR, 1H-NMR, and 13CNMR) spectroscopy. All synthesized compounds were evaluated for antibacterial activities in vitro against Gram-positive and Gram-negative bacteria.
Conclusion: All compounds were purely synthesized, and all compounds were indicated growth inhibition against Escherichia coli, and Staphylococcus aureus, respectively with different inhibition zones staring from 13 to 33 mm. |
| first_indexed | 2024-12-21T12:44:19Z |
| format | Article |
| id | doaj.art-d88b0f10749646618daebb440a03bb16 |
| institution | Directory Open Access Journal |
| issn | 1995-5588 1995-5596 |
| language | English |
| last_indexed | 2024-12-21T12:44:19Z |
| publishDate | 2019-08-01 |
| publisher | Hawler Medical University |
| record_format | Article |
| series | Zanco Journal of Medical Sciences |
| spelling | doaj.art-d88b0f10749646618daebb440a03bb162022-12-21T19:03:42ZengHawler Medical UniversityZanco Journal of Medical Sciences1995-55881995-55962019-08-0123220621610.15218/zjms.2019.026Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazoleSarbast Muhammed Ahmed0Kezhal M. Salih1Hiwa Omer Ahmad2Zanko H. Jawhar3Dashti H. Hamad4Hawler Medical UniversityHawler Medical UniversityAynda Private Technical InstituteHawler Medical UniversityHawler Medical UniversityBackground and objective: Compounds having imine or azomethine (–C=N–) functional group are known as Schiff bases. Schiff bases compounds are found to be an active pharmacophore for the design and development of various bioactive lead compounds. In this study, several new Schiff base compounds have been synthesized and characterized. Methods: Williamson ether synthesis process has been used to synthesize -alkyloxy and substituted benzyloxy of benzaldehyde. Differently substituted ether benzaldehydes used to react with 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one in one hand and 1H-benzo[d]imidazol-2-amine on the other hand to produce Schiff base compounds. Results: Synthesized ether derivative compounds (3a-e) were converted to new series of Schiff bases (4a-e and 5a-e) by condensation of equal molar amounts of compounds (3a-e) with different heterocyclic amines dissolved in absolute ethanol. All synthesized compounds were confirmed by (IR, 1H-NMR, and 13CNMR) spectroscopy. All synthesized compounds were evaluated for antibacterial activities in vitro against Gram-positive and Gram-negative bacteria. Conclusion: All compounds were purely synthesized, and all compounds were indicated growth inhibition against Escherichia coli, and Staphylococcus aureus, respectively with different inhibition zones staring from 13 to 33 mm.https://zjms.hmu.edu.krd/index.php/zjms/article/view/677/578Schiff baseWilliamson ether synthesisBiological activityAzomethine |
| spellingShingle | Sarbast Muhammed Ahmed Kezhal M. Salih Hiwa Omer Ahmad Zanko H. Jawhar Dashti H. Hamad Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazole Zanco Journal of Medical Sciences Schiff base Williamson ether synthesis Biological activity Azomethine |
| title | Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazole |
| title_full | Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazole |
| title_fullStr | Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazole |
| title_full_unstemmed | Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazole |
| title_short | Synthesis, spectroscopic characterization and antibacterial activity of new series of Schiff base derived from 4-aminoantipyrine and 2-amino benzimidazole |
| title_sort | synthesis spectroscopic characterization and antibacterial activity of new series of schiff base derived from 4 aminoantipyrine and 2 amino benzimidazole |
| topic | Schiff base Williamson ether synthesis Biological activity Azomethine |
| url | https://zjms.hmu.edu.krd/index.php/zjms/article/view/677/578 |
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