CYSTATIN C AS A SCREENING BIOMARKER OF GESTATIONAL DIABETES MELLITUS
Objective: To evaluate cystatin C as a screening biomarker for early detection of gestational diabetes mellitus (GDM). Study Design: Case control study. Place and Duration of Study: Army Medical College and Pak Emirates Military Hospital, from Dec 2017 Jun 2018. Methodology: This case contr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2020-08-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/5100/2859 |
| _version_ | 1818919139163504640 |
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| author | Sadia Israr Asma Hayat Tariq Mahmood Ahmad Qurat Ul Ain Amna Saddique Numan Majeed |
| author_facet | Sadia Israr Asma Hayat Tariq Mahmood Ahmad Qurat Ul Ain Amna Saddique Numan Majeed |
| author_sort | Sadia Israr |
| collection | DOAJ |
| description | Objective: To evaluate cystatin C as a screening biomarker for early detection of gestational diabetes mellitus (GDM).
Study Design: Case control study.
Place and Duration of Study: Army Medical College and Pak Emirates Military Hospital, from Dec 2017 Jun 2018.
Methodology: This case control study was conducted at department of Chemical Pathology, Army Medical College and Pak Emirates Military Hospital Rawalpindi. A total of 30 women with gestational diabetes (cases) and 30 healthy pregnant women (control) were recruited in the study. HbA1c, cystatin C and insulin levels were performed on samples of all the participants. Seventy-five gram OGGT was performed on all subjects. Paired t-test and Odds ratio were calculated for cases and controls.
Results: The cystatin C levels were high with increasing parity. Paired sample t test showed strong association of cystatin C to HbA1c, fasting and post load glucose levels in patients of GDM (HbA1c t (60)=36.0, p<0.001, Fasting glucose t (60) = 34.3, p<0.001, One-hour glucose t (60)=27.6, p<0.001 and Two hours glucose t (60)=22.9, p<0.001). Adjusted odds ratios (OR) based on cut off value of cystatin C (>0.95) of maternal plasma showed positive association with one-hour (OR=4.7) and two-hour (OR=4.3) post load plasma glucose levels in OGTT.
Conclusion: This study strongly suggested that cystatin C may be used as preliminary screening biomarker for early detection of GDM. Patients having elevated levels of cystatin C then can be further evaluated using OGTT. This two-step approach has potential to rationalize the diagnostic work up of this category of patients and would also result in evidence-based patient management. |
| first_indexed | 2024-12-20T01:01:06Z |
| format | Article |
| id | doaj.art-d88d79008c05445e852af78b23b29c79 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-20T01:01:06Z |
| publishDate | 2020-08-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-d88d79008c05445e852af78b23b29c792022-12-21T19:59:00ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422020-08-0170410961100CYSTATIN C AS A SCREENING BIOMARKER OF GESTATIONAL DIABETES MELLITUSSadia Israr0Asma Hayat1Tariq Mahmood Ahmad2Qurat Ul Ain3Amna Saddique4Numan Majeed5Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanObjective: To evaluate cystatin C as a screening biomarker for early detection of gestational diabetes mellitus (GDM). Study Design: Case control study. Place and Duration of Study: Army Medical College and Pak Emirates Military Hospital, from Dec 2017 Jun 2018. Methodology: This case control study was conducted at department of Chemical Pathology, Army Medical College and Pak Emirates Military Hospital Rawalpindi. A total of 30 women with gestational diabetes (cases) and 30 healthy pregnant women (control) were recruited in the study. HbA1c, cystatin C and insulin levels were performed on samples of all the participants. Seventy-five gram OGGT was performed on all subjects. Paired t-test and Odds ratio were calculated for cases and controls. Results: The cystatin C levels were high with increasing parity. Paired sample t test showed strong association of cystatin C to HbA1c, fasting and post load glucose levels in patients of GDM (HbA1c t (60)=36.0, p<0.001, Fasting glucose t (60) = 34.3, p<0.001, One-hour glucose t (60)=27.6, p<0.001 and Two hours glucose t (60)=22.9, p<0.001). Adjusted odds ratios (OR) based on cut off value of cystatin C (>0.95) of maternal plasma showed positive association with one-hour (OR=4.7) and two-hour (OR=4.3) post load plasma glucose levels in OGTT. Conclusion: This study strongly suggested that cystatin C may be used as preliminary screening biomarker for early detection of GDM. Patients having elevated levels of cystatin C then can be further evaluated using OGTT. This two-step approach has potential to rationalize the diagnostic work up of this category of patients and would also result in evidence-based patient management.https://www.pafmj.org/index.php/PAFMJ/article/view/5100/2859cystatin cgdm |
| spellingShingle | Sadia Israr Asma Hayat Tariq Mahmood Ahmad Qurat Ul Ain Amna Saddique Numan Majeed CYSTATIN C AS A SCREENING BIOMARKER OF GESTATIONAL DIABETES MELLITUS Pakistan Armed Forces Medical Journal cystatin c gdm |
| title | CYSTATIN C AS A SCREENING BIOMARKER OF GESTATIONAL DIABETES MELLITUS |
| title_full | CYSTATIN C AS A SCREENING BIOMARKER OF GESTATIONAL DIABETES MELLITUS |
| title_fullStr | CYSTATIN C AS A SCREENING BIOMARKER OF GESTATIONAL DIABETES MELLITUS |
| title_full_unstemmed | CYSTATIN C AS A SCREENING BIOMARKER OF GESTATIONAL DIABETES MELLITUS |
| title_short | CYSTATIN C AS A SCREENING BIOMARKER OF GESTATIONAL DIABETES MELLITUS |
| title_sort | cystatin c as a screening biomarker of gestational diabetes mellitus |
| topic | cystatin c gdm |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/5100/2859 |
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