Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study
AbstractObjective Evaluating the prevalence of long-COVID symptoms in patients with a history of mild or asymptomatic infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the factors associated with developing long-COVID.Design A nationwide cohort study. Using a centralize...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-07-01
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| Series: | Scandinavian Journal of Primary Health Care |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02813432.2022.2139480 |
| _version_ | 1797955928493916160 |
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| author | Limor Adler Sivan Gazit Yuval Pinto Galit Perez Miri Mizrahi Reuveni Ilan Yehoshua Robert Hoffman Joseph Azuri Tal Patalon |
| author_facet | Limor Adler Sivan Gazit Yuval Pinto Galit Perez Miri Mizrahi Reuveni Ilan Yehoshua Robert Hoffman Joseph Azuri Tal Patalon |
| author_sort | Limor Adler |
| collection | DOAJ |
| description | AbstractObjective Evaluating the prevalence of long-COVID symptoms in patients with a history of mild or asymptomatic infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the factors associated with developing long-COVID.Design A nationwide cohort study. Using a centralized database, we have identified patients with and without a history of SARS-CoV-2 infection 1–6 months before data collection. Patients were asked to fill out an online questionnaire through text messages.Setting Israeli general practice.Subjects 2755 persons participated in the study in September 2021 (a response rate of 7.5%): 819 with and, 936 without a history of SARS-CoV-2 infection.Main outcome measures We asked patients to provide details about their demographic status, medical history, COVID-related variables and the presence of long-COVID symptoms.Results Most prevalent long-COVID symptoms were decreased smell sensation (35.1% vs. 4.3%, p < 0.001), decreased taste sensation (25.2% vs. 3.2%, p < 0.001), memory disturbances (36.9% vs. 14.4%, p < 0.001), dyspnea (24.2% vs. 10.7%, p < 0.001) and arthralgia (33% vs. 16.3%, p < 0.001). Risk factors associated with long-COVID included female gender, symptomatic COVID-19, overweight or obesity and the presence of dyslipidemia. About 34.6% of participants reported not returning to their baseline health condition after the acute illness.Conclusion Long-COVID is frequently seen following a mild symptomatic COVID-19 infection and, to a lesser extent, following an asymptomatic SARS-CoV-2 infection. Primary care physicians should be aware of these symptoms and consider this option in their differential diagnosis. Health policymakers should expect a significant impact of this syndrome on public health.Key PointsLong-COVID has emerged as a significant health problem with a serious impact on normal daily function• Long-COVID symptoms were evident in patients with mild symptomatic disease and in asymptomatic patients to a lesser extent.• Risk factors for having Long-COVID symptoms include female gender, symptomatic disease, increased BMI, and the presence of dyslipidemia.• Fatigue, dyspnea, weakness, decreased libido, weight changes, memory, and sleep disturbances were associated with not returning to the baseline health state. |
| first_indexed | 2024-04-10T23:40:52Z |
| format | Article |
| id | doaj.art-d88f8dd5a7074768bd944b2013cccd3d |
| institution | Directory Open Access Journal |
| issn | 0281-3432 1502-7724 |
| language | English |
| last_indexed | 2024-04-10T23:40:52Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Scandinavian Journal of Primary Health Care |
| spelling | doaj.art-d88f8dd5a7074768bd944b2013cccd3d2023-01-11T09:10:37ZengTaylor & Francis GroupScandinavian Journal of Primary Health Care0281-34321502-77242022-07-0140334234910.1080/02813432.2022.2139480Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort StudyLimor Adler0Sivan Gazit1Yuval Pinto2Galit Perez3Miri Mizrahi Reuveni4Ilan Yehoshua5Robert Hoffman6Joseph Azuri7Tal Patalon8Health Division, Maccabi Healthcare Services, Tel Aviv, IsraelKahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, IsraelFamily Medicine Residency Program, Meritus Medical Center, Hagerstwon, MD, USAMaccabitech Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv, IsraelHealth Division, Maccabi Healthcare Services, Tel Aviv, IsraelHealth Division, Maccabi Healthcare Services, Tel Aviv, IsraelHealth Division, Maccabi Healthcare Services, Tel Aviv, IsraelHealth Division, Maccabi Healthcare Services, Tel Aviv, IsraelKahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, IsraelAbstractObjective Evaluating the prevalence of long-COVID symptoms in patients with a history of mild or asymptomatic infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the factors associated with developing long-COVID.Design A nationwide cohort study. Using a centralized database, we have identified patients with and without a history of SARS-CoV-2 infection 1–6 months before data collection. Patients were asked to fill out an online questionnaire through text messages.Setting Israeli general practice.Subjects 2755 persons participated in the study in September 2021 (a response rate of 7.5%): 819 with and, 936 without a history of SARS-CoV-2 infection.Main outcome measures We asked patients to provide details about their demographic status, medical history, COVID-related variables and the presence of long-COVID symptoms.Results Most prevalent long-COVID symptoms were decreased smell sensation (35.1% vs. 4.3%, p < 0.001), decreased taste sensation (25.2% vs. 3.2%, p < 0.001), memory disturbances (36.9% vs. 14.4%, p < 0.001), dyspnea (24.2% vs. 10.7%, p < 0.001) and arthralgia (33% vs. 16.3%, p < 0.001). Risk factors associated with long-COVID included female gender, symptomatic COVID-19, overweight or obesity and the presence of dyslipidemia. About 34.6% of participants reported not returning to their baseline health condition after the acute illness.Conclusion Long-COVID is frequently seen following a mild symptomatic COVID-19 infection and, to a lesser extent, following an asymptomatic SARS-CoV-2 infection. Primary care physicians should be aware of these symptoms and consider this option in their differential diagnosis. Health policymakers should expect a significant impact of this syndrome on public health.Key PointsLong-COVID has emerged as a significant health problem with a serious impact on normal daily function• Long-COVID symptoms were evident in patients with mild symptomatic disease and in asymptomatic patients to a lesser extent.• Risk factors for having Long-COVID symptoms include female gender, symptomatic disease, increased BMI, and the presence of dyslipidemia.• Fatigue, dyspnea, weakness, decreased libido, weight changes, memory, and sleep disturbances were associated with not returning to the baseline health state.https://www.tandfonline.com/doi/10.1080/02813432.2022.2139480Long-COVIDSARS-CoV-2 infectionmild diseaseasymptomatic diseasecohort studies |
| spellingShingle | Limor Adler Sivan Gazit Yuval Pinto Galit Perez Miri Mizrahi Reuveni Ilan Yehoshua Robert Hoffman Joseph Azuri Tal Patalon Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study Scandinavian Journal of Primary Health Care Long-COVID SARS-CoV-2 infection mild disease asymptomatic disease cohort studies |
| title | Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study |
| title_full | Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study |
| title_fullStr | Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study |
| title_full_unstemmed | Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study |
| title_short | Long-COVID in patients with a history of mild or asymptomatic SARS-CoV-2 infection: a Nationwide Cohort Study |
| title_sort | long covid in patients with a history of mild or asymptomatic sars cov 2 infection a nationwide cohort study |
| topic | Long-COVID SARS-CoV-2 infection mild disease asymptomatic disease cohort studies |
| url | https://www.tandfonline.com/doi/10.1080/02813432.2022.2139480 |
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