NEK1-Mediated Phosphorylation of YAP1 Is Key to Prostate Cancer Progression

NEK1-Mediated Phosphorylation of YAP1 Is Key to Prostate Cancer Progression

The key to preventing mCRPC progression is understanding how androgen-dependent PCa cells progress to independence and modify their transcriptional repertoire accordingly. We recently identified a novel axis of the Hippo pathway characterized by the sequential kinase cascade induced by androgen depr...

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Bibliographic Details
Main Authors: Ishita Ghosh, Md Imtiaz Khalil, Rusella Mirza, Judy King, Damilola Olatunde, Arrigo De Benedetti
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
TLK
NEK1
YAP1
prostate cancer
AR
EMT
Online Access:https://www.mdpi.com/2227-9059/11/3/734

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