Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO-cryopreserved platelets

Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO-cryopreserved platelets

Background: Freezing is promising for extended platelet (PLT) storage for transfusion. 6% DMSO cryopreserved PLTs (CPPs) are currently in clinical development. CPPs contain significant amount of platelet membrane vesicles (PMVs). PLT-membrane changes and PMV release in CPP are poorly understood, and...

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Bibliographic Details
Main Authors:	Tseday Z. Tegegn, Silvia H. De Paoli, Martina Orecna, Oumsalama K. Elhelu, Samuel A. Woodle, Ivan D. Tarandovskiy, Mikhail V. Ovanesov, Jan Simak
Format:	Article
Language:	English
Published:	Wiley 2016-05-01
Series:	Journal of Extracellular Vesicles
Subjects:	extracellular vesicles microparticles platelet physiology blood products thrombin transfusion medicine nanoparticle tracking analysis flow cytometry atomic force microscopy electron microscopy
Online Access:	http://www.journalofextracellularvesicles.net/index.php/jev/article/view/30422/pdf_60

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