Potential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarction
Abstract Inflammation plays an important role in the development of heart failure (HF) after myocardial infarction (MI). Suppression of post-infarction inflammatory cascade has become a new strategy to delay or block the progression of HF. At present, there are no approved anti-inflammatory drugs us...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
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| Series: | Chinese Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13020-023-00732-w |
| _version_ | 1797863567077146624 |
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| author | Zhen Zhang Fei Chen Jingjing Wan Xia Liu |
| author_facet | Zhen Zhang Fei Chen Jingjing Wan Xia Liu |
| author_sort | Zhen Zhang |
| collection | DOAJ |
| description | Abstract Inflammation plays an important role in the development of heart failure (HF) after myocardial infarction (MI). Suppression of post-infarction inflammatory cascade has become a new strategy to delay or block the progression of HF. At present, there are no approved anti-inflammatory drugs used to prevent HF following MI. Traditional Chinese medicine (TCM) has been used clinically for cardiovascular disease for a long time. Here, we summarized the recent progress about some TCM which could both improve cardiac function and inhibit inflammation in patients or experimental models with MI or HF, in order to provide evidence for their potential application in reducing the onset of HF following MI. Among them, single Chinese medicinal herbs (eg. Astragalus and Salvia miltiorrhiza) and Chinese herbal formulas (eg. Gualou Xiebai Decoction and Sini Tang) are discussed separately. The main targets for their anti-inflammation effect are mainly involved the TLR4/NF-κB signaling, as well as pro-inflammatory cytokines IL-1β, IL-6 or TNF-α. It is worthy of further evaluating their potential, experimentally or clinically, in the prevention or delay of HF following MI. |
| first_indexed | 2024-04-09T22:38:40Z |
| format | Article |
| id | doaj.art-d8912d395e09462090098309004ebd20 |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-04-09T22:38:40Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj.art-d8912d395e09462090098309004ebd202023-03-22T12:22:37ZengBMCChinese Medicine1749-85462023-03-0118111510.1186/s13020-023-00732-wPotential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarctionZhen Zhang0Fei Chen1Jingjing Wan2Xia Liu3Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical UniversityDepartment of Clinical Pharmacy, School of Pharmacy, Second Military Medical UniversityDepartment of Clinical Pharmacy, School of Pharmacy, Second Military Medical UniversityDepartment of Clinical Pharmacy, School of Pharmacy, Second Military Medical UniversityAbstract Inflammation plays an important role in the development of heart failure (HF) after myocardial infarction (MI). Suppression of post-infarction inflammatory cascade has become a new strategy to delay or block the progression of HF. At present, there are no approved anti-inflammatory drugs used to prevent HF following MI. Traditional Chinese medicine (TCM) has been used clinically for cardiovascular disease for a long time. Here, we summarized the recent progress about some TCM which could both improve cardiac function and inhibit inflammation in patients or experimental models with MI or HF, in order to provide evidence for their potential application in reducing the onset of HF following MI. Among them, single Chinese medicinal herbs (eg. Astragalus and Salvia miltiorrhiza) and Chinese herbal formulas (eg. Gualou Xiebai Decoction and Sini Tang) are discussed separately. The main targets for their anti-inflammation effect are mainly involved the TLR4/NF-κB signaling, as well as pro-inflammatory cytokines IL-1β, IL-6 or TNF-α. It is worthy of further evaluating their potential, experimentally or clinically, in the prevention or delay of HF following MI.https://doi.org/10.1186/s13020-023-00732-wMyocardial infarctionInflammationTraditional Chinese medicineHeart failure |
| spellingShingle | Zhen Zhang Fei Chen Jingjing Wan Xia Liu Potential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarction Chinese Medicine Myocardial infarction Inflammation Traditional Chinese medicine Heart failure |
| title | Potential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarction |
| title_full | Potential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarction |
| title_fullStr | Potential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarction |
| title_full_unstemmed | Potential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarction |
| title_short | Potential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarction |
| title_sort | potential traditional chinese medicines with anti inflammation in the prevention of heart failure following myocardial infarction |
| topic | Myocardial infarction Inflammation Traditional Chinese medicine Heart failure |
| url | https://doi.org/10.1186/s13020-023-00732-w |
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