Modified natriuretic peptides and their potential roles in cancer treatment
The natriuretic peptide family (NPs) is a group of natural endocrine hormones, containing a 17-amino acid ring structure connected by disulfide bonds of two cysteines. In this review, the members of the natriuretic peptide family and their corresponding receptors as well as the anti-cancer effects a...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417021000858 |
| _version_ | 1828112567540645888 |
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| author | Mengjiao Xu Xingzhu Liu Ping Li Yadong Yang Wenyuan Zhang Siyu Zhao Ying Zeng Xile Zhou Ling-hui Zeng Geng Yang |
| author_facet | Mengjiao Xu Xingzhu Liu Ping Li Yadong Yang Wenyuan Zhang Siyu Zhao Ying Zeng Xile Zhou Ling-hui Zeng Geng Yang |
| author_sort | Mengjiao Xu |
| collection | DOAJ |
| description | The natriuretic peptide family (NPs) is a group of natural endocrine hormones, containing a 17-amino acid ring structure connected by disulfide bonds of two cysteines. In this review, the members of the natriuretic peptide family and their corresponding receptors as well as the anti-cancer effects are introduced. Four cardiac hormones of NPs (ANP, VD, KP and LANP) can effectively inhibit the growth of human small cell lung cancer, breast cancer and other tumors and significantly reduce tumor volume in vivo. The in vitro experiments also show that cardiac hormones, CNP and urodilatin can effectively inhibit the growth of most tumor cells. We then further summarized the anti-cancer mechanism of natriuretic peptides. Finally, we introduce several methods that modify natriuretic peptides, leading to enhance their stability and prolong the biological effects of these peptides, which might be helpful for the clinical application in the future. Peptide therapy is a very promising field for cancer treatments since they can induce the death of cancer cells without dramatically affecting normal cells. The synthesis of a useful and stable natriuretic peptide can enhance the effect of cancer treatments and significantly reduce drug resistance and toxicity. |
| first_indexed | 2024-04-11T11:51:26Z |
| format | Article |
| id | doaj.art-d892522f0a864dadba81621f2578b625 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-11T11:51:26Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-d892522f0a864dadba81621f2578b6252022-12-22T04:25:20ZengElsevierBiomedical Journal2319-41702022-02-01451118131Modified natriuretic peptides and their potential roles in cancer treatmentMengjiao Xu0Xingzhu Liu1Ping Li2Yadong Yang3Wenyuan Zhang4Siyu Zhao5Ying Zeng6Xile Zhou7Ling-hui Zeng8Geng Yang9Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, China; School of Bioengineering, Hangzhou Medical College, Hangzhou, ChinaSchool of Bioengineering, Hangzhou Medical College, Hangzhou, ChinaSchool of Bioengineering, Hangzhou Medical College, Hangzhou, ChinaSchool of Bioengineering, Hangzhou Medical College, Hangzhou, ChinaSchool of Bioengineering, Hangzhou Medical College, Hangzhou, ChinaSchool of Bioengineering, Hangzhou Medical College, Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, ChinaDepartment of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, China; Corresponding author. Department of Pharmacology, School of Medicine, Zhejiang University City College, 48, Huzhou St., Hangzhou 310015, ChinaThe natriuretic peptide family (NPs) is a group of natural endocrine hormones, containing a 17-amino acid ring structure connected by disulfide bonds of two cysteines. In this review, the members of the natriuretic peptide family and their corresponding receptors as well as the anti-cancer effects are introduced. Four cardiac hormones of NPs (ANP, VD, KP and LANP) can effectively inhibit the growth of human small cell lung cancer, breast cancer and other tumors and significantly reduce tumor volume in vivo. The in vitro experiments also show that cardiac hormones, CNP and urodilatin can effectively inhibit the growth of most tumor cells. We then further summarized the anti-cancer mechanism of natriuretic peptides. Finally, we introduce several methods that modify natriuretic peptides, leading to enhance their stability and prolong the biological effects of these peptides, which might be helpful for the clinical application in the future. Peptide therapy is a very promising field for cancer treatments since they can induce the death of cancer cells without dramatically affecting normal cells. The synthesis of a useful and stable natriuretic peptide can enhance the effect of cancer treatments and significantly reduce drug resistance and toxicity.http://www.sciencedirect.com/science/article/pii/S2319417021000858Natriuretic peptides (NPs)Cancer treatmentNatriuretic peptide modificationPeptide therapy |
| spellingShingle | Mengjiao Xu Xingzhu Liu Ping Li Yadong Yang Wenyuan Zhang Siyu Zhao Ying Zeng Xile Zhou Ling-hui Zeng Geng Yang Modified natriuretic peptides and their potential roles in cancer treatment Biomedical Journal Natriuretic peptides (NPs) Cancer treatment Natriuretic peptide modification Peptide therapy |
| title | Modified natriuretic peptides and their potential roles in cancer treatment |
| title_full | Modified natriuretic peptides and their potential roles in cancer treatment |
| title_fullStr | Modified natriuretic peptides and their potential roles in cancer treatment |
| title_full_unstemmed | Modified natriuretic peptides and their potential roles in cancer treatment |
| title_short | Modified natriuretic peptides and their potential roles in cancer treatment |
| title_sort | modified natriuretic peptides and their potential roles in cancer treatment |
| topic | Natriuretic peptides (NPs) Cancer treatment Natriuretic peptide modification Peptide therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2319417021000858 |
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