Mechanisms and effects of metformin on skeletal muscle disorders
Skeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1275266/full |
| _version_ | 1797656083387383808 |
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| author | Ren Shang Jing Miao |
| author_facet | Ren Shang Jing Miao |
| author_sort | Ren Shang |
| collection | DOAJ |
| description | Skeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically, hence the development of novel treatments for neuromuscular diseases is crucial to obtain a better quality of life. As a widely used hypoglycemic drug in clinical practice, metformin not only has anti-inflammatory, autophagy-regulating, and mitochondrial biogenesis-regulating effects, but it has also been reported to improve the symptoms of neuromuscular diseases, delay hypokinesia, and regulate skeletal muscle mass. However, metformin’s specific mechanism of action in neuromuscular diseases requires further elucidation. This review summarizes the evidence showing that metformin can regulate inflammation, autophagy, and mitochondrial biogenesis through different pathways, and further explores its mechanism of action in Duchenne muscular dystrophy, statin-associated muscle disorders, and age-related sarcopenia. This review clarifies the directions of future research on therapy for neuromuscular diseases. |
| first_indexed | 2024-03-11T17:24:13Z |
| format | Article |
| id | doaj.art-d897bdae0a98430199a5cf8efcc0a84f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T17:24:13Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d897bdae0a98430199a5cf8efcc0a84f2023-10-19T08:04:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.12752661275266Mechanisms and effects of metformin on skeletal muscle disordersRen ShangJing MiaoSkeletal muscle disorders are mostly genetic and include several rare diseases. With disease progression, muscle fibrosis and adiposis occur, resulting in limited mobility. The long course of these diseases combined with limited treatment options affect patients both psychologically and economically, hence the development of novel treatments for neuromuscular diseases is crucial to obtain a better quality of life. As a widely used hypoglycemic drug in clinical practice, metformin not only has anti-inflammatory, autophagy-regulating, and mitochondrial biogenesis-regulating effects, but it has also been reported to improve the symptoms of neuromuscular diseases, delay hypokinesia, and regulate skeletal muscle mass. However, metformin’s specific mechanism of action in neuromuscular diseases requires further elucidation. This review summarizes the evidence showing that metformin can regulate inflammation, autophagy, and mitochondrial biogenesis through different pathways, and further explores its mechanism of action in Duchenne muscular dystrophy, statin-associated muscle disorders, and age-related sarcopenia. This review clarifies the directions of future research on therapy for neuromuscular diseases.https://www.frontiersin.org/articles/10.3389/fneur.2023.1275266/fullmetformininflammationautophagymitochondrial biogenesisskeletal muscle disorders |
| spellingShingle | Ren Shang Jing Miao Mechanisms and effects of metformin on skeletal muscle disorders Frontiers in Neurology metformin inflammation autophagy mitochondrial biogenesis skeletal muscle disorders |
| title | Mechanisms and effects of metformin on skeletal muscle disorders |
| title_full | Mechanisms and effects of metformin on skeletal muscle disorders |
| title_fullStr | Mechanisms and effects of metformin on skeletal muscle disorders |
| title_full_unstemmed | Mechanisms and effects of metformin on skeletal muscle disorders |
| title_short | Mechanisms and effects of metformin on skeletal muscle disorders |
| title_sort | mechanisms and effects of metformin on skeletal muscle disorders |
| topic | metformin inflammation autophagy mitochondrial biogenesis skeletal muscle disorders |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1275266/full |
| work_keys_str_mv | AT renshang mechanismsandeffectsofmetforminonskeletalmuscledisorders AT jingmiao mechanismsandeffectsofmetforminonskeletalmuscledisorders |