Antimicrobial and Phytochemistry study of Dendrobium linearifolium Teijsm. & Binn. from Gumitir, Jember, Indonesia
Dendrobium linearifolium Teijsm. & Binn. is an epiphytic orchid growing in Mount Gumitir, Jember, Indonesia and had been used by indigenous people of Bali to treat earaches. Previous research has identified its DNA barcode and the presence of alkaloids and flavonoids with the highest concentrati...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2024/20/bioconf_icolib2023_01001.pdf |
| _version_ | 1797213214065295360 |
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| author | Setyati Dwi Su’udi Mukhamad Ravitamala El Shania Fajriah Miladina Fitrotul Babudin Babudin Utarti Esti Arimurti Sattya Satia Nugraha Ari Ananda Putri Yusi Maulana Farhan Abdillah Bahrul Ulum Fuad |
| author_facet | Setyati Dwi Su’udi Mukhamad Ravitamala El Shania Fajriah Miladina Fitrotul Babudin Babudin Utarti Esti Arimurti Sattya Satia Nugraha Ari Ananda Putri Yusi Maulana Farhan Abdillah Bahrul Ulum Fuad |
| author_sort | Setyati Dwi |
| collection | DOAJ |
| description | Dendrobium linearifolium Teijsm. & Binn. is an epiphytic orchid growing in Mount Gumitir, Jember, Indonesia and had been used by indigenous people of Bali to treat earaches. Previous research has identified its DNA barcode and the presence of alkaloids and flavonoids with the highest concentration found in the leaves. However, an extensive analysis of their chemical constituents and their potential medicinal properties from this plant is not yet available. This study aims to determine the antimicrobial activity and phytochemical contents of the methanol extract of D. linearifolium leaves. The antimicrobial test was conducted using the agar diffusion method against two fungi: Aspergillus niger and Aspergillus falvus and three pathogenic bacteria i.e., Streptococcus aureus, Salmonella typhi, and Escherichia coli. Phytochemical analysis was performed using GC-MS. The results of the antimicrobial test indicate that the extract of D. linearifolium leaves possessed antimicrobial activity with the highest level against A. niger and the gram-positive bacteria S. aureus. The phytochemical analysis detected a total of 47 compounds with a total of 26 having medicinal potential. The five most dominant compounds with antimicrobial activity, i.e., 1-propanol, 2-(2-hydroxypropoxy)- (CAS) 2-(2-hydroxypropoxy)-1-propanol; 4-methyl-2,5-dimethoxybenzaldehyde; phenol, 2-methoxy- (CAS) guaiacol; 2-propanol, 1,1′-oxybis- (CAS) dipropylene glycol; and acetic acid (CAS) ethylic acid. |
| first_indexed | 2024-04-24T10:54:43Z |
| format | Article |
| id | doaj.art-d898e8aa909d4a4cb71ca28da71ff14d |
| institution | Directory Open Access Journal |
| issn | 2117-4458 |
| language | English |
| last_indexed | 2024-04-24T10:54:43Z |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj.art-d898e8aa909d4a4cb71ca28da71ff14d2024-04-12T07:37:14ZengEDP SciencesBIO Web of Conferences2117-44582024-01-011010100110.1051/bioconf/202410101001bioconf_icolib2023_01001Antimicrobial and Phytochemistry study of Dendrobium linearifolium Teijsm. & Binn. from Gumitir, Jember, IndonesiaSetyati Dwi0Su’udi Mukhamad1Ravitamala El Shania2Fajriah Miladina Fitrotul3Babudin Babudin4Utarti Esti5Arimurti Sattya6Satia Nugraha Ari7Ananda Putri Yusi8Maulana Farhan Abdillah9Bahrul Ulum Fuad10Laboratory of Botany, Biology Department, Jember UniversityLaboratory of Botany, Biology Department, Jember UniversityLaboratory of Botany, Biology Department, Jember UniversityLaboratory of Botany, Biology Department, Jember UniversityLaboratory of Botany, Biology Department, Jember UniversityLaboratory of Microbiology, Biology Department, Jember UniversityLaboratory of Microbiology, Biology Department, Jember UniversityDrug Utilisation and Discovery Research Group, Faculty of Pharmacy, Jember UniversityLaboratory of Botany, Biology Department, Jember UniversityLaboratory of Botany, Biology Department, Jember UniversityLaboratory of Botany, Biology Department, Jember UniversityDendrobium linearifolium Teijsm. & Binn. is an epiphytic orchid growing in Mount Gumitir, Jember, Indonesia and had been used by indigenous people of Bali to treat earaches. Previous research has identified its DNA barcode and the presence of alkaloids and flavonoids with the highest concentration found in the leaves. However, an extensive analysis of their chemical constituents and their potential medicinal properties from this plant is not yet available. This study aims to determine the antimicrobial activity and phytochemical contents of the methanol extract of D. linearifolium leaves. The antimicrobial test was conducted using the agar diffusion method against two fungi: Aspergillus niger and Aspergillus falvus and three pathogenic bacteria i.e., Streptococcus aureus, Salmonella typhi, and Escherichia coli. Phytochemical analysis was performed using GC-MS. The results of the antimicrobial test indicate that the extract of D. linearifolium leaves possessed antimicrobial activity with the highest level against A. niger and the gram-positive bacteria S. aureus. The phytochemical analysis detected a total of 47 compounds with a total of 26 having medicinal potential. The five most dominant compounds with antimicrobial activity, i.e., 1-propanol, 2-(2-hydroxypropoxy)- (CAS) 2-(2-hydroxypropoxy)-1-propanol; 4-methyl-2,5-dimethoxybenzaldehyde; phenol, 2-methoxy- (CAS) guaiacol; 2-propanol, 1,1′-oxybis- (CAS) dipropylene glycol; and acetic acid (CAS) ethylic acid.https://www.bio-conferences.org/articles/bioconf/pdf/2024/20/bioconf_icolib2023_01001.pdf |
| spellingShingle | Setyati Dwi Su’udi Mukhamad Ravitamala El Shania Fajriah Miladina Fitrotul Babudin Babudin Utarti Esti Arimurti Sattya Satia Nugraha Ari Ananda Putri Yusi Maulana Farhan Abdillah Bahrul Ulum Fuad Antimicrobial and Phytochemistry study of Dendrobium linearifolium Teijsm. & Binn. from Gumitir, Jember, Indonesia BIO Web of Conferences |
| title | Antimicrobial and Phytochemistry study of Dendrobium linearifolium Teijsm. & Binn. from Gumitir, Jember, Indonesia |
| title_full | Antimicrobial and Phytochemistry study of Dendrobium linearifolium Teijsm. & Binn. from Gumitir, Jember, Indonesia |
| title_fullStr | Antimicrobial and Phytochemistry study of Dendrobium linearifolium Teijsm. & Binn. from Gumitir, Jember, Indonesia |
| title_full_unstemmed | Antimicrobial and Phytochemistry study of Dendrobium linearifolium Teijsm. & Binn. from Gumitir, Jember, Indonesia |
| title_short | Antimicrobial and Phytochemistry study of Dendrobium linearifolium Teijsm. & Binn. from Gumitir, Jember, Indonesia |
| title_sort | antimicrobial and phytochemistry study of dendrobium linearifolium teijsm binn from gumitir jember indonesia |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2024/20/bioconf_icolib2023_01001.pdf |
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