Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fraction

Summary: Heart failure with preserved ejection fraction is an increasing challenge for modern day medicine and has been drawing more attention recently. Invasive right heart catheterization represents the mainstay for the diagnosis of diastolic dysfunction, however due to its attributable risk of an...

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Main Authors: Alexander Schulz, Andreas Schuster
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005515
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author Alexander Schulz
Andreas Schuster
author_facet Alexander Schulz
Andreas Schuster
author_sort Alexander Schulz
collection DOAJ
description Summary: Heart failure with preserved ejection fraction is an increasing challenge for modern day medicine and has been drawing more attention recently. Invasive right heart catheterization represents the mainstay for the diagnosis of diastolic dysfunction, however due to its attributable risk of an invasive procedure, other non-invasive clinical pathways are trying to approach this pathology in clinical practice. Diastolic failure is complex, and imaging is based on various parameters. In addition to transthoracic echocardiography, numerous novel imaging approaches, such as cardiac magnetic resonance imaging, computed tomography, positron emission (computed) tomography or single photon emission tomography techniques are being used to supplement deeper insights into causal pathology and might open targets for dedicated therapy options. This article provides insights into these sophisticated imaging techniques, their incremental value for the diagnosis of this poorly understood disease and recent promising results for an enhanced prognostication of outcome and therapy monitoring.
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spelling doaj.art-d89a15b295f74c5c8d279c65b86f03d62022-12-22T02:47:55ZengElsevierEBioMedicine2352-39642022-12-0186104369Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fractionAlexander Schulz0Andreas Schuster1Department of Cardiology and Pneumology, Georg-August University, University Medical Center Göttingen, Göttingen, GermanyCorresponding author. Department for Cardiology and Pneumology, University Medical Center, Georg-August University, Robert-Koch-Str. 40, 37099 Göttingen, Germany.; Department of Cardiology and Pneumology, Georg-August University, University Medical Center Göttingen, Göttingen, GermanySummary: Heart failure with preserved ejection fraction is an increasing challenge for modern day medicine and has been drawing more attention recently. Invasive right heart catheterization represents the mainstay for the diagnosis of diastolic dysfunction, however due to its attributable risk of an invasive procedure, other non-invasive clinical pathways are trying to approach this pathology in clinical practice. Diastolic failure is complex, and imaging is based on various parameters. In addition to transthoracic echocardiography, numerous novel imaging approaches, such as cardiac magnetic resonance imaging, computed tomography, positron emission (computed) tomography or single photon emission tomography techniques are being used to supplement deeper insights into causal pathology and might open targets for dedicated therapy options. This article provides insights into these sophisticated imaging techniques, their incremental value for the diagnosis of this poorly understood disease and recent promising results for an enhanced prognostication of outcome and therapy monitoring.http://www.sciencedirect.com/science/article/pii/S2352396422005515HFpEFDiastolic dysfunctionNon-invasive imagingImaging markers
spellingShingle Alexander Schulz
Andreas Schuster
Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fraction
EBioMedicine
HFpEF
Diastolic dysfunction
Non-invasive imaging
Imaging markers
title Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fraction
title_full Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fraction
title_fullStr Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fraction
title_full_unstemmed Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fraction
title_short Visualizing diastolic failure: Non-invasive imaging-biomarkers in patients with heart failure with preserved ejection fraction
title_sort visualizing diastolic failure non invasive imaging biomarkers in patients with heart failure with preserved ejection fraction
topic HFpEF
Diastolic dysfunction
Non-invasive imaging
Imaging markers
url http://www.sciencedirect.com/science/article/pii/S2352396422005515
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