The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease
The excessive activation of the renin-angiotensin system in kidney disease leads to alteration of intracellular pathways which concur altogether to the induction of cardiovascular and renal remodeling, exposing these patients since the very beginning of the renal injury to chronic kidney disease and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/7/1041 |
| _version_ | 1797528491640487936 |
|---|---|
| author | Verdiana Ravarotto Giovanni Bertoldi Georgie Innico Laura Gobbi Lorenzo A. Calò |
| author_facet | Verdiana Ravarotto Giovanni Bertoldi Georgie Innico Laura Gobbi Lorenzo A. Calò |
| author_sort | Verdiana Ravarotto |
| collection | DOAJ |
| description | The excessive activation of the renin-angiotensin system in kidney disease leads to alteration of intracellular pathways which concur altogether to the induction of cardiovascular and renal remodeling, exposing these patients since the very beginning of the renal injury to chronic kidney disease and progression to end stage renal disease, a very harmful and life threatening clinical condition. Oxidative stress plays a pivotal role in the pathophysiology of renal injury and cardiovascular-renal remodeling, the long-term consequence of its effect. This review will examine the role of oxidative stress in the most significant pathways involved in cardiovascular and renal remodeling with a focus on the detrimental effects of oxidative stress-mediated renal abnormalities on the progression of the disease and of its complications. Food for thoughts on possible therapeutic target are proposed on the basis of experimental evidences. |
| first_indexed | 2024-03-10T09:59:05Z |
| format | Article |
| id | doaj.art-d89aa256a2fc4d8b88842c1b29d9c7ec |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T09:59:05Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-d89aa256a2fc4d8b88842c1b29d9c7ec2023-11-22T02:06:44ZengMDPI AGAntioxidants2076-39212021-06-01107104110.3390/antiox10071041The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney DiseaseVerdiana Ravarotto0Giovanni Bertoldi1Georgie Innico2Laura Gobbi3Lorenzo A. Calò4Nephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyThe excessive activation of the renin-angiotensin system in kidney disease leads to alteration of intracellular pathways which concur altogether to the induction of cardiovascular and renal remodeling, exposing these patients since the very beginning of the renal injury to chronic kidney disease and progression to end stage renal disease, a very harmful and life threatening clinical condition. Oxidative stress plays a pivotal role in the pathophysiology of renal injury and cardiovascular-renal remodeling, the long-term consequence of its effect. This review will examine the role of oxidative stress in the most significant pathways involved in cardiovascular and renal remodeling with a focus on the detrimental effects of oxidative stress-mediated renal abnormalities on the progression of the disease and of its complications. Food for thoughts on possible therapeutic target are proposed on the basis of experimental evidences.https://www.mdpi.com/2076-3921/10/7/1041oxidative stressrenin-angiotensin systemcardiovascular diseasechronic kidney diseasedialysis |
| spellingShingle | Verdiana Ravarotto Giovanni Bertoldi Georgie Innico Laura Gobbi Lorenzo A. Calò The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease Antioxidants oxidative stress renin-angiotensin system cardiovascular disease chronic kidney disease dialysis |
| title | The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease |
| title_full | The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease |
| title_fullStr | The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease |
| title_full_unstemmed | The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease |
| title_short | The Pivotal Role of Oxidative Stress in the Pathophysiology of Cardiovascular-Renal Remodeling in Kidney Disease |
| title_sort | pivotal role of oxidative stress in the pathophysiology of cardiovascular renal remodeling in kidney disease |
| topic | oxidative stress renin-angiotensin system cardiovascular disease chronic kidney disease dialysis |
| url | https://www.mdpi.com/2076-3921/10/7/1041 |
| work_keys_str_mv | AT verdianaravarotto thepivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT giovannibertoldi thepivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT georgieinnico thepivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT lauragobbi thepivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT lorenzoacalo thepivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT verdianaravarotto pivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT giovannibertoldi pivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT georgieinnico pivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT lauragobbi pivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease AT lorenzoacalo pivotalroleofoxidativestressinthepathophysiologyofcardiovascularrenalremodelinginkidneydisease |