Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease
Midbrain dopamine neurons have crucial functions in motor and emotional control and their degeneration leads to several neurological dysfunctions such as Parkinson’s disease, addiction, depression, schizophrenia, and others. Despite advances in the understanding of specific altered proteins and codi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/9/1269 |
| _version_ | 1797554737007034368 |
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| author | Emilia Pascale Giuseppina Divisato Renata Palladino Margherita Auriemma Edward Faustine Ngalya Massimiliano Caiazzo |
| author_facet | Emilia Pascale Giuseppina Divisato Renata Palladino Margherita Auriemma Edward Faustine Ngalya Massimiliano Caiazzo |
| author_sort | Emilia Pascale |
| collection | DOAJ |
| description | Midbrain dopamine neurons have crucial functions in motor and emotional control and their degeneration leads to several neurological dysfunctions such as Parkinson’s disease, addiction, depression, schizophrenia, and others. Despite advances in the understanding of specific altered proteins and coding genes, little is known about cumulative changes in the transcriptional landscape of noncoding genes in midbrain dopamine neurons. Noncoding RNAs—specifically microRNAs and long noncoding RNAs—are emerging as crucial post-transcriptional regulators of gene expression in the brain. The identification of noncoding RNA networks underlying all stages of dopamine neuron development and plasticity is an essential step to deeply understand their physiological role and also their involvement in the etiology of dopaminergic diseases. Here, we provide an update about noncoding RNAs involved in dopaminergic development and metabolism, and the related evidence of these biomolecules for applications in potential treatments for dopaminergic neurodegeneration. |
| first_indexed | 2024-03-10T16:36:19Z |
| format | Article |
| id | doaj.art-d89aa34e72444d4b89430b883afb4e2c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T16:36:19Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d89aa34e72444d4b89430b883afb4e2c2023-11-20T12:24:48ZengMDPI AGBiomolecules2218-273X2020-09-01109126910.3390/biom10091269Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and DiseaseEmilia Pascale0Giuseppina Divisato1Renata Palladino2Margherita Auriemma3Edward Faustine Ngalya4Massimiliano Caiazzo5Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyMidbrain dopamine neurons have crucial functions in motor and emotional control and their degeneration leads to several neurological dysfunctions such as Parkinson’s disease, addiction, depression, schizophrenia, and others. Despite advances in the understanding of specific altered proteins and coding genes, little is known about cumulative changes in the transcriptional landscape of noncoding genes in midbrain dopamine neurons. Noncoding RNAs—specifically microRNAs and long noncoding RNAs—are emerging as crucial post-transcriptional regulators of gene expression in the brain. The identification of noncoding RNA networks underlying all stages of dopamine neuron development and plasticity is an essential step to deeply understand their physiological role and also their involvement in the etiology of dopaminergic diseases. Here, we provide an update about noncoding RNAs involved in dopaminergic development and metabolism, and the related evidence of these biomolecules for applications in potential treatments for dopaminergic neurodegeneration.https://www.mdpi.com/2218-273X/10/9/1269microRNAlong noncoding RNAdopamine neuronsParkinson’s diseasedirect cell conversion or reprogrammingRNA therapeutics |
| spellingShingle | Emilia Pascale Giuseppina Divisato Renata Palladino Margherita Auriemma Edward Faustine Ngalya Massimiliano Caiazzo Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease Biomolecules microRNA long noncoding RNA dopamine neurons Parkinson’s disease direct cell conversion or reprogramming RNA therapeutics |
| title | Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease |
| title_full | Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease |
| title_fullStr | Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease |
| title_full_unstemmed | Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease |
| title_short | Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease |
| title_sort | noncoding rnas and midbrain da neurons novel molecular mechanisms and therapeutic targets in health and disease |
| topic | microRNA long noncoding RNA dopamine neurons Parkinson’s disease direct cell conversion or reprogramming RNA therapeutics |
| url | https://www.mdpi.com/2218-273X/10/9/1269 |
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