Myocardial Viability Testing in the Management of Ischemic Heart Failure
Although major advances have occurred lately in medical therapy, ischemic heart failure remains an important cause of death and disability. Viable myocardium represents a cause of reversible ischemic left ventricular dysfunction. Coronary revascularization may improve left ventricular function and p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/11/1760 |
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| author | Elena Emilia Babes Delia Mirela Tit Alexa Florina Bungau Cristiana Bustea Marius Rus Simona Gabriela Bungau Victor Vlad Babes |
| author_facet | Elena Emilia Babes Delia Mirela Tit Alexa Florina Bungau Cristiana Bustea Marius Rus Simona Gabriela Bungau Victor Vlad Babes |
| author_sort | Elena Emilia Babes |
| collection | DOAJ |
| description | Although major advances have occurred lately in medical therapy, ischemic heart failure remains an important cause of death and disability. Viable myocardium represents a cause of reversible ischemic left ventricular dysfunction. Coronary revascularization may improve left ventricular function and prognosis in patients with viable myocardium. Although patients with impaired left ventricular function and multi-vessel coronary artery disease benefit the most from revascularization, they are at high risk of complications related to revascularization procedure. An important element in selecting the patients for myocardial revascularization is the presence of the viable myocardium. Multiple imaging modalities can assess myocardial viability and predict functional improvement after revascularization, with dobutamine stress echocardiography, nuclear imaging tests and magnetic resonance imaging being the most frequently used. However, the role of myocardial viability testing in the management of patients with ischemic heart failure is still controversial due to the failure of randomized controlled trials of revascularization to reveal clear benefits of viability testing. This review summarizes the current knowledge regarding the concept of viable myocardium, depicts the role and tools for viability testing, discusses the research involving this topic and the controversies related to the utility of myocardial viability testing and provides a patient-centered approach for clinical practice. |
| first_indexed | 2024-03-09T18:56:11Z |
| format | Article |
| id | doaj.art-d89af23918284734af962682c1cd5ebf |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T18:56:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-d89af23918284734af962682c1cd5ebf2023-11-24T05:30:30ZengMDPI AGLife2075-17292022-11-011211176010.3390/life12111760Myocardial Viability Testing in the Management of Ischemic Heart FailureElena Emilia Babes0Delia Mirela Tit1Alexa Florina Bungau2Cristiana Bustea3Marius Rus4Simona Gabriela Bungau5Victor Vlad Babes6Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaDoctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, RomaniaDepartment of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaAlthough major advances have occurred lately in medical therapy, ischemic heart failure remains an important cause of death and disability. Viable myocardium represents a cause of reversible ischemic left ventricular dysfunction. Coronary revascularization may improve left ventricular function and prognosis in patients with viable myocardium. Although patients with impaired left ventricular function and multi-vessel coronary artery disease benefit the most from revascularization, they are at high risk of complications related to revascularization procedure. An important element in selecting the patients for myocardial revascularization is the presence of the viable myocardium. Multiple imaging modalities can assess myocardial viability and predict functional improvement after revascularization, with dobutamine stress echocardiography, nuclear imaging tests and magnetic resonance imaging being the most frequently used. However, the role of myocardial viability testing in the management of patients with ischemic heart failure is still controversial due to the failure of randomized controlled trials of revascularization to reveal clear benefits of viability testing. This review summarizes the current knowledge regarding the concept of viable myocardium, depicts the role and tools for viability testing, discusses the research involving this topic and the controversies related to the utility of myocardial viability testing and provides a patient-centered approach for clinical practice.https://www.mdpi.com/2075-1729/12/11/1760coronary artery diseaseheart failureischemic cardiomyopathyleft ventricular functionmyocardial viability |
| spellingShingle | Elena Emilia Babes Delia Mirela Tit Alexa Florina Bungau Cristiana Bustea Marius Rus Simona Gabriela Bungau Victor Vlad Babes Myocardial Viability Testing in the Management of Ischemic Heart Failure Life coronary artery disease heart failure ischemic cardiomyopathy left ventricular function myocardial viability |
| title | Myocardial Viability Testing in the Management of Ischemic Heart Failure |
| title_full | Myocardial Viability Testing in the Management of Ischemic Heart Failure |
| title_fullStr | Myocardial Viability Testing in the Management of Ischemic Heart Failure |
| title_full_unstemmed | Myocardial Viability Testing in the Management of Ischemic Heart Failure |
| title_short | Myocardial Viability Testing in the Management of Ischemic Heart Failure |
| title_sort | myocardial viability testing in the management of ischemic heart failure |
| topic | coronary artery disease heart failure ischemic cardiomyopathy left ventricular function myocardial viability |
| url | https://www.mdpi.com/2075-1729/12/11/1760 |
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