A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics
Multicellular organisms and the saprophytic flora form complex, highly integrated chimeric systems (associative symbioses, metaorganisms) characterized by interplay between pro- and eukaryotic components. To be able to interact symbiotically microorganisms (MO) need a whole body.When grown on artifi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2020-09-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.elpub.ru/jour/article/view/872 |
| _version_ | 1828257438116085760 |
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| author | Natalia A. Mikhailova Dmitry A. Voevodin Sergey A. Lazarev |
| author_facet | Natalia A. Mikhailova Dmitry A. Voevodin Sergey A. Lazarev |
| author_sort | Natalia A. Mikhailova |
| collection | DOAJ |
| description | Multicellular organisms and the saprophytic flora form complex, highly integrated chimeric systems (associative symbioses, metaorganisms) characterized by interplay between pro- and eukaryotic components. To be able to interact symbiotically microorganisms (MO) need a whole body.When grown on artificial media for a long time, symbiotic MO have to adapt to the artificial environment and gradually, though reversibly, lose their ability of associative interaction with the human body, thus causing a decrease in the therapeutic efficacy of MO-derived probiotic products. To increase the therapeutic activity of probiotic MO, they must be functionally rehabilitated.A pathological process induces development of a secondary metabolic dysbiosis; as a result, changes in the regulatory processes of an individual interfere with the restoration of the normal microflora. Therefore, functional rehabilitation of probiotic MO must take place during cultivation, while the cultivation process must replicate the whole-body conditions. |
| first_indexed | 2024-04-13T02:41:40Z |
| format | Article |
| id | doaj.art-d89b2c2678e74711a4ce814607540097 |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-04-13T02:41:40Z |
| publishDate | 2020-09-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-d89b2c2678e74711a4ce8146075400972022-12-22T03:06:11ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132020-09-0197434635510.36233/0372-9311-2020-97-4-7668A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probioticsNatalia A. Mikhailova0Dmitry A. Voevodin1Sergey A. Lazarev2Mechnikov Research Institute for Vaccines and SeraMechnikov Research Institute for Vaccines and SeraMechnikov Research Institute for Vaccines and SeraMulticellular organisms and the saprophytic flora form complex, highly integrated chimeric systems (associative symbioses, metaorganisms) characterized by interplay between pro- and eukaryotic components. To be able to interact symbiotically microorganisms (MO) need a whole body.When grown on artificial media for a long time, symbiotic MO have to adapt to the artificial environment and gradually, though reversibly, lose their ability of associative interaction with the human body, thus causing a decrease in the therapeutic efficacy of MO-derived probiotic products. To increase the therapeutic activity of probiotic MO, they must be functionally rehabilitated.A pathological process induces development of a secondary metabolic dysbiosis; as a result, changes in the regulatory processes of an individual interfere with the restoration of the normal microflora. Therefore, functional rehabilitation of probiotic MO must take place during cultivation, while the cultivation process must replicate the whole-body conditions.https://microbiol.elpub.ru/jour/article/view/872probioticsregulatory peptidesprotein hydrolysatedysbiosiscorrection |
| spellingShingle | Natalia A. Mikhailova Dmitry A. Voevodin Sergey A. Lazarev A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics Журнал микробиологии, эпидемиологии и иммунобиологии probiotics regulatory peptides protein hydrolysate dysbiosis correction |
| title | A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics |
| title_full | A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics |
| title_fullStr | A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics |
| title_full_unstemmed | A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics |
| title_short | A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics |
| title_sort | modern view of pro eukaryote interactions in the human body as the basis for development of next generation probiotics |
| topic | probiotics regulatory peptides protein hydrolysate dysbiosis correction |
| url | https://microbiol.elpub.ru/jour/article/view/872 |
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