Effects of Hydro Alcoholic Extraction of Valeriana on Astrocyte Raphe Magnus in Adult Rats
Introduction & aim: valerian root extraction is used in the treatment of sleep disorders, stress, depression, anxiety, muscle stiffness and tension. Astrocytes have role of nutrition, protection and support of the neurons. The purpose of this study was to investigate the effects of Valeriana ext...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | fas |
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Yasuj University Of Medical Sciences
2014-12-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-33&slc_lang=en&sid=1 |
| _version_ | 1811236341937078272 |
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| author | sajad Hatami joni ali , Rahmani tibi islam Askarpour jamshid Mohammadi merzad Jafari sahar , Almasi tork amrollah Rozbehi |
| author_facet | sajad Hatami joni ali , Rahmani tibi islam Askarpour jamshid Mohammadi merzad Jafari sahar , Almasi tork amrollah Rozbehi |
| author_sort | sajad Hatami joni |
| collection | DOAJ |
| description | Introduction & aim: valerian root extraction is used in the treatment of sleep disorders, stress, depression, anxiety, muscle stiffness and tension. Astrocytes have role of nutrition, protection and support of the neurons. The purpose of this study was to investigate the effects of Valeriana extract on nucleus raphe magnus in the number and size of rat astrocytes.
Methods: In the present experimental study, forty male Wistar rats weighing170-250g were randomly divided into four groups, including control and three experimental groups. The control group received distilled water and three experimental groups received 300, 400 and 600mg valerian root extract daily respectively for two weeks by gavage. Phsophotangestic acid staining was used to examine astrocytes. The size and number of astrocytes were calculated with LS.starter software. Data were analyzed, using SPSS software for statistical analysis and ANOVA and LSD tests.
Results: The mean number of astrocytes in the experimental groups of three and four with the control group and experimental two showed a significant increase (P <0.05). Compare mean of great length of astrocytes in experimental groups of two, three and four with the control group showed a significant decrease and between the experimental group two and experimental groups of three and four a statistically significant differences were observed (P <0.05).
Conclusion: Oral administration of hydro alcoholic extract of valerian increases astrocytes number and decreases their size in nucleus of raphe Magna, which indicated the effect of this extraction on proliferation of astrocytes increasing. |
| first_indexed | 2024-04-12T12:07:18Z |
| format | Article |
| id | doaj.art-d89c4579eb6a40288ce59e04b213efd1 |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-12T12:07:18Z |
| publishDate | 2014-12-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-d89c4579eb6a40288ce59e04b213efd12022-12-22T03:33:40ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142014-12-01199771779Effects of Hydro Alcoholic Extraction of Valeriana on Astrocyte Raphe Magnus in Adult Ratssajad Hatami joni0ali , Rahmani tibi1islam Askarpour2jamshid Mohammadi3merzad Jafari4sahar , Almasi tork5amrollah Rozbehi6 1Student Research Committee,Yasuj University of Medical Sciences, Yasuj, Iran 1Student Research Committee,Yasuj University of Medical Sciences, Yasuj, Iran 1Student Research Committee,Yasuj University of Medical Sciences, Yasuj, Iran Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran 3Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Department of Anatomical Sciences, Bushehr University of Medical Sciences, Bushehr, Iran, 3Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Introduction & aim: valerian root extraction is used in the treatment of sleep disorders, stress, depression, anxiety, muscle stiffness and tension. Astrocytes have role of nutrition, protection and support of the neurons. The purpose of this study was to investigate the effects of Valeriana extract on nucleus raphe magnus in the number and size of rat astrocytes. Methods: In the present experimental study, forty male Wistar rats weighing170-250g were randomly divided into four groups, including control and three experimental groups. The control group received distilled water and three experimental groups received 300, 400 and 600mg valerian root extract daily respectively for two weeks by gavage. Phsophotangestic acid staining was used to examine astrocytes. The size and number of astrocytes were calculated with LS.starter software. Data were analyzed, using SPSS software for statistical analysis and ANOVA and LSD tests. Results: The mean number of astrocytes in the experimental groups of three and four with the control group and experimental two showed a significant increase (P <0.05). Compare mean of great length of astrocytes in experimental groups of two, three and four with the control group showed a significant decrease and between the experimental group two and experimental groups of three and four a statistically significant differences were observed (P <0.05). Conclusion: Oral administration of hydro alcoholic extract of valerian increases astrocytes number and decreases their size in nucleus of raphe Magna, which indicated the effect of this extraction on proliferation of astrocytes increasing.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-33&slc_lang=en&sid=1 extract valerian astrocytes raphe Magnus rat |
| spellingShingle | sajad Hatami joni ali , Rahmani tibi islam Askarpour jamshid Mohammadi merzad Jafari sahar , Almasi tork amrollah Rozbehi Effects of Hydro Alcoholic Extraction of Valeriana on Astrocyte Raphe Magnus in Adult Rats Armaghane Danesh Bimonthly Journal extract valerian astrocytes raphe Magnus rat |
| title | Effects of Hydro Alcoholic Extraction of Valeriana on Astrocyte Raphe Magnus in Adult Rats |
| title_full | Effects of Hydro Alcoholic Extraction of Valeriana on Astrocyte Raphe Magnus in Adult Rats |
| title_fullStr | Effects of Hydro Alcoholic Extraction of Valeriana on Astrocyte Raphe Magnus in Adult Rats |
| title_full_unstemmed | Effects of Hydro Alcoholic Extraction of Valeriana on Astrocyte Raphe Magnus in Adult Rats |
| title_short | Effects of Hydro Alcoholic Extraction of Valeriana on Astrocyte Raphe Magnus in Adult Rats |
| title_sort | effects of hydro alcoholic extraction of valeriana on astrocyte raphe magnus in adult rats |
| topic | extract valerian astrocytes raphe Magnus rat |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-1-33&slc_lang=en&sid=1 |
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