Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis
Venous thromboembolism (VTE) is one of the leading causes of post-operative morbidity and mortality. Over previous decades, heparin and warfarin were the predominant therapeutic options for post-operative thromboprophylaxis. However, their use is limited by drawbacks including a narrow therapeutic r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2022-05-01
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| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articleindex/ecr.2021.55 |
| _version_ | 1797200012989431808 |
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| author | Han Naung Tun May Thu Kyaw Erik Rafflenbeul Xiuhtlaulli López Suástegui |
| author_facet | Han Naung Tun May Thu Kyaw Erik Rafflenbeul Xiuhtlaulli López Suástegui |
| author_sort | Han Naung Tun |
| collection | DOAJ |
| description | Venous thromboembolism (VTE) is one of the leading causes of post-operative morbidity and mortality. Over previous decades, heparin and warfarin were the predominant therapeutic options for post-operative thromboprophylaxis. However, their use is limited by drawbacks including a narrow therapeutic range, numerous food and drug interactions, and the need for regular monitoring for dose adjustments. Recently, direct oral anticoagulants (DOACs), such as dabigatran etexilate (a direct thrombin inhibitor) and apixaban, rivaroxaban and edoxaban (direct factor Xa inhibitors), have been developed to overcome these issues. DOACs have shown promising results in Phase III clinical trials for post-operative VTE prophylaxis. This review summarises the pharmacological profile of DOACs and highlights the use of DOACs in post-operative VTE prophylaxis based on the available clinical trial data. |
| first_indexed | 2024-03-07T17:40:22Z |
| format | Article |
| id | doaj.art-d89d062f08114b408d57e9fec71cbcaf |
| institution | Directory Open Access Journal |
| issn | 1758-3756 1758-3764 |
| language | English |
| last_indexed | 2024-04-24T07:24:53Z |
| publishDate | 2022-05-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj.art-d89d062f08114b408d57e9fec71cbcaf2024-04-20T16:02:51ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642022-05-011710.15420/ecr.2021.55Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism ProphylaxisHan Naung Tun0May Thu Kyaw1Erik Rafflenbeul2Xiuhtlaulli López Suástegui3Larner College of Medicine, University of Vermont, Burlington, VT, USHeart and Vascular Centre, Victoria Hospital, Yangon, MyanmarDepartment of Cardiology, Schoen Clinic Hamburg Eilbek, Hamburg, GermanyEmergency Department, Intensive Care Unit Hospital Regional de Alta Especialidad de Zumpango, Instituto Mexicano del Seguro Social, Zumpango de Ocampo, MexicoVenous thromboembolism (VTE) is one of the leading causes of post-operative morbidity and mortality. Over previous decades, heparin and warfarin were the predominant therapeutic options for post-operative thromboprophylaxis. However, their use is limited by drawbacks including a narrow therapeutic range, numerous food and drug interactions, and the need for regular monitoring for dose adjustments. Recently, direct oral anticoagulants (DOACs), such as dabigatran etexilate (a direct thrombin inhibitor) and apixaban, rivaroxaban and edoxaban (direct factor Xa inhibitors), have been developed to overcome these issues. DOACs have shown promising results in Phase III clinical trials for post-operative VTE prophylaxis. This review summarises the pharmacological profile of DOACs and highlights the use of DOACs in post-operative VTE prophylaxis based on the available clinical trial data.https://www.ecrjournal.com/articleindex/ecr.2021.55 |
| spellingShingle | Han Naung Tun May Thu Kyaw Erik Rafflenbeul Xiuhtlaulli López Suástegui Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis European Cardiology Review |
| title | Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis |
| title_full | Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis |
| title_fullStr | Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis |
| title_full_unstemmed | Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis |
| title_short | Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis |
| title_sort | role of direct oral anticoagulants for post operative venous thromboembolism prophylaxis |
| url | https://www.ecrjournal.com/articleindex/ecr.2021.55 |
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