The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study
Abstract Background To explore prognostic value of the pre-treatment primary lesion apparent diffusion coefficient (ADC) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Methods A total of 843 patients with newly diagnosed LA-NPC were enrolled from January 2011 to April 2014 and divided...
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BMC
2019-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-5684-3 |
| _version_ | 1828878748656599040 |
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| author | Tao-xiang Huang Nian Lu Shan-shan Lian Hui Li Shao-han Yin Zhi-jun Geng Chuan-miao Xie |
| author_facet | Tao-xiang Huang Nian Lu Shan-shan Lian Hui Li Shao-han Yin Zhi-jun Geng Chuan-miao Xie |
| author_sort | Tao-xiang Huang |
| collection | DOAJ |
| description | Abstract Background To explore prognostic value of the pre-treatment primary lesion apparent diffusion coefficient (ADC) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Methods A total of 843 patients with newly diagnosed LA-NPC were enrolled from January 2011 to April 2014 and divided into two groups based on ADC values: the low-ADC group and high-ADC group. The 3-year local relapse-free survival (LRFS), distant metastasis free survival (DMFS), disease-free survival (DFS) and overall survival (OS) rates between two groups were compared using Kaplan-Meier curve, and Cox regression analyses were performed to test prognostic value of the pretreatment ADC in LA-NPC. Results The cut-off value of the pretreatment ADC for predicting local relapse was 784.5 × 10 − 6 mm2/s (AUC [area under curve] = 0.604; sensitivity = 0.640; specificity = 0.574), thus patients were divided into low-ADC (< 784.5 × 10 − 6; n = 473) group and high-ADC (≥784.5 × 10 − 6; n = 370) group. The low-ADC group had significantly higher 3-year LRFS rate and DFS rate than the high-ADC group (LRFS: 96.2% vs. 91.4%, P = 0.003; DFS: 81.4% vs. 73.0%, P = 0.0056). Multivariate analysis showed that the pretreatment ADC is an independent prognostic factor for LRFS (HR, 2.04; 95% CI, 1.13–3.66; P = 0.017) and DFS (HR, 1.41; 95% CI, 1.04–1.89; P = 0.024). Conclusions The pretreatment ADC of the primary lesion is an independent prognostic factor for LRFS and DFS in LA-NPC patients. |
| first_indexed | 2024-12-13T09:12:20Z |
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| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-13T09:12:20Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj.art-d89d309b52474d5eba8d390a45d758b82022-12-21T23:52:54ZengBMCBMC Cancer1471-24072019-05-011911810.1186/s12885-019-5684-3The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective studyTao-xiang Huang0Nian Lu1Shan-shan Lian2Hui Li3Shao-han Yin4Zhi-jun Geng5Chuan-miao Xie6Department of Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern ChinaDepartment of Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern ChinaDepartment of Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern ChinaDepartment of Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern ChinaDepartment of Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern ChinaDepartment of Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern ChinaDepartment of Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in Southern ChinaAbstract Background To explore prognostic value of the pre-treatment primary lesion apparent diffusion coefficient (ADC) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Methods A total of 843 patients with newly diagnosed LA-NPC were enrolled from January 2011 to April 2014 and divided into two groups based on ADC values: the low-ADC group and high-ADC group. The 3-year local relapse-free survival (LRFS), distant metastasis free survival (DMFS), disease-free survival (DFS) and overall survival (OS) rates between two groups were compared using Kaplan-Meier curve, and Cox regression analyses were performed to test prognostic value of the pretreatment ADC in LA-NPC. Results The cut-off value of the pretreatment ADC for predicting local relapse was 784.5 × 10 − 6 mm2/s (AUC [area under curve] = 0.604; sensitivity = 0.640; specificity = 0.574), thus patients were divided into low-ADC (< 784.5 × 10 − 6; n = 473) group and high-ADC (≥784.5 × 10 − 6; n = 370) group. The low-ADC group had significantly higher 3-year LRFS rate and DFS rate than the high-ADC group (LRFS: 96.2% vs. 91.4%, P = 0.003; DFS: 81.4% vs. 73.0%, P = 0.0056). Multivariate analysis showed that the pretreatment ADC is an independent prognostic factor for LRFS (HR, 2.04; 95% CI, 1.13–3.66; P = 0.017) and DFS (HR, 1.41; 95% CI, 1.04–1.89; P = 0.024). Conclusions The pretreatment ADC of the primary lesion is an independent prognostic factor for LRFS and DFS in LA-NPC patients.http://link.springer.com/article/10.1186/s12885-019-5684-3Locoregionally advanced nasopharyngeal carcinomaMagnetic resonance imagingApparent diffusion coefficientPrognosis |
| spellingShingle | Tao-xiang Huang Nian Lu Shan-shan Lian Hui Li Shao-han Yin Zhi-jun Geng Chuan-miao Xie The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study BMC Cancer Locoregionally advanced nasopharyngeal carcinoma Magnetic resonance imaging Apparent diffusion coefficient Prognosis |
| title | The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study |
| title_full | The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study |
| title_fullStr | The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study |
| title_full_unstemmed | The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study |
| title_short | The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study |
| title_sort | primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma a retrospective study |
| topic | Locoregionally advanced nasopharyngeal carcinoma Magnetic resonance imaging Apparent diffusion coefficient Prognosis |
| url | http://link.springer.com/article/10.1186/s12885-019-5684-3 |
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