A New Optimization Strategy of Highly Branched Poly(β-Amino Ester) for Enhanced Gene Delivery: Removal of Small Molecular Weight Components

A New Optimization Strategy of Highly Branched Poly(β-Amino Ester) for Enhanced Gene Delivery: Removal of Small Molecular Weight Components

Highly branched poly(β-amino ester) (HPAE) has become one of the most promising non-viral gene delivery vector candidates. When compared to other gene delivery vectors, HPAE has a broad molecular weight distribution (MWD). Despite significant efforts to optimize HPAE targeting enhanced gene delivery...

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Bibliographic Details
Main Authors: Yinghao Li, Xianqing Wang, Zhonglei He, Zishan Li, Melissa Johnson, Bei Qiu, Rijian Song, Sigen A, Irene Lara-Sáez, Jing Lyu, Wenxin Wang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Polymers
Subjects:
gene transfection
highly branched poly(<i>β</i>-amino ester)
non-viral vector
polymer component
pDNA delivery
step-wise precipitation
Online Access:https://www.mdpi.com/2073-4360/15/6/1518

Internet

https://www.mdpi.com/2073-4360/15/6/1518

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