Primary lateral sclerosis plus parkinsonism: a case report
Abstract Background The standard of diagnosing primary lateral sclerosis, the Pringle criteria, requires three years of purely upper motor neuron symptom presentation before confirming diagnosis. This classic standard has been questioned on occasion due to its restrictive range of both time period a...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-023-03360-x |
| _version_ | 1797452201571909632 |
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| author | Abhaya Moturu Wade Welch |
| author_facet | Abhaya Moturu Wade Welch |
| author_sort | Abhaya Moturu |
| collection | DOAJ |
| description | Abstract Background The standard of diagnosing primary lateral sclerosis, the Pringle criteria, requires three years of purely upper motor neuron symptom presentation before confirming diagnosis. This classic standard has been questioned on occasion due to its restrictive range of both time period and symptomatic exhibition. Case presentation This case report will review a 57-year-old Caucasian female who presented with pyramidal and extrapyramidal features suggestive of the exceedingly rare disease primary lateral sclerosis plus parkinsonism. We will describe the mixture of upper motor neuron signs and striking parkinsonian symptoms experienced by the patient, as well as the full diagnostic workup leading to her preliminary diagnosis. The details of this case will then be utilized to explore the diagnostic criteria of primary lateral sclerosis, as well as to work through the differential of conditions resembling Parkinson’s disease. Conclusions The current criteria to diagnose primary lateral sclerosis may be excluding patients with the disease and is an ongoing area of investigation. A thorough differential including other neurodegenerative conditions is necessary to consider and requires long-term follow-up. |
| first_indexed | 2024-03-09T15:05:21Z |
| format | Article |
| id | doaj.art-d89f4c3671f74ce6a6ff5bba88d97393 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-09T15:05:21Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-d89f4c3671f74ce6a6ff5bba88d973932023-11-26T13:42:07ZengBMCBMC Neurology1471-23772023-08-012311710.1186/s12883-023-03360-xPrimary lateral sclerosis plus parkinsonism: a case reportAbhaya Moturu0Wade Welch1Department of Neurology, University of Kansas St. Francis Health SystemDepartment of Neurology, University of Kansas St. Francis Health SystemAbstract Background The standard of diagnosing primary lateral sclerosis, the Pringle criteria, requires three years of purely upper motor neuron symptom presentation before confirming diagnosis. This classic standard has been questioned on occasion due to its restrictive range of both time period and symptomatic exhibition. Case presentation This case report will review a 57-year-old Caucasian female who presented with pyramidal and extrapyramidal features suggestive of the exceedingly rare disease primary lateral sclerosis plus parkinsonism. We will describe the mixture of upper motor neuron signs and striking parkinsonian symptoms experienced by the patient, as well as the full diagnostic workup leading to her preliminary diagnosis. The details of this case will then be utilized to explore the diagnostic criteria of primary lateral sclerosis, as well as to work through the differential of conditions resembling Parkinson’s disease. Conclusions The current criteria to diagnose primary lateral sclerosis may be excluding patients with the disease and is an ongoing area of investigation. A thorough differential including other neurodegenerative conditions is necessary to consider and requires long-term follow-up.https://doi.org/10.1186/s12883-023-03360-xPrimary lateral sclerosisParkinsonismUpper motor neuron symptomsPyramidal featuresExtrapyramidal features |
| spellingShingle | Abhaya Moturu Wade Welch Primary lateral sclerosis plus parkinsonism: a case report BMC Neurology Primary lateral sclerosis Parkinsonism Upper motor neuron symptoms Pyramidal features Extrapyramidal features |
| title | Primary lateral sclerosis plus parkinsonism: a case report |
| title_full | Primary lateral sclerosis plus parkinsonism: a case report |
| title_fullStr | Primary lateral sclerosis plus parkinsonism: a case report |
| title_full_unstemmed | Primary lateral sclerosis plus parkinsonism: a case report |
| title_short | Primary lateral sclerosis plus parkinsonism: a case report |
| title_sort | primary lateral sclerosis plus parkinsonism a case report |
| topic | Primary lateral sclerosis Parkinsonism Upper motor neuron symptoms Pyramidal features Extrapyramidal features |
| url | https://doi.org/10.1186/s12883-023-03360-x |
| work_keys_str_mv | AT abhayamoturu primarylateralsclerosisplusparkinsonismacasereport AT wadewelch primarylateralsclerosisplusparkinsonismacasereport |