Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature
Preeclampsia is a multisystemic clinical syndrome characterized by the appearance of new-onset hypertension and proteinuria or hypertension and end organ dysfunction even without proteinuria after 20 weeks of pregnancy or postpartum. Residing at the severe end of the spectrum of the hypertensive dis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/5/826 |
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| author | Sevasti Koulouraki Vasileios Paschos Panagiota Pervanidou Panagiotis Christopoulos Angeliki Gerede Makarios Eleftheriades |
| author_facet | Sevasti Koulouraki Vasileios Paschos Panagiota Pervanidou Panagiotis Christopoulos Angeliki Gerede Makarios Eleftheriades |
| author_sort | Sevasti Koulouraki |
| collection | DOAJ |
| description | Preeclampsia is a multisystemic clinical syndrome characterized by the appearance of new-onset hypertension and proteinuria or hypertension and end organ dysfunction even without proteinuria after 20 weeks of pregnancy or postpartum. Residing at the severe end of the spectrum of the hypertensive disorders of pregnancy, preeclampsia occurs in 3 to 8% of pregnancies worldwide and is a major cause of maternal and perinatal morbidity and mortality, accounting for 8–10% of all preterm births. The mechanism whereby preeclampsia increases the risk of the neurodevelopmental, cardiovascular, and metabolic morbidity of the mother’s offspring is not well known, but it is possible that the preeclamptic environment induces epigenetic changes that adversely affect developmental plasticity. These developmental changes are crucial for optimal fetal growth and survival but may lead to an increased risk of chronic morbidity in childhood and even later in life. The aim of this review is to summarize both the short- and long-term effects of preeclampsia on offspring based on the current literature. |
| first_indexed | 2024-03-11T03:51:10Z |
| format | Article |
| id | doaj.art-d89f754541074a72acb1710850c25389 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T03:51:10Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-d89f754541074a72acb1710850c253892023-11-18T00:55:28ZengMDPI AGChildren2227-90672023-05-0110582610.3390/children10050826Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the LiteratureSevasti Koulouraki0Vasileios Paschos1Panagiota Pervanidou2Panagiotis Christopoulos3Angeliki Gerede4Makarios Eleftheriades5Second Department of Obstetrics and Gynaecology, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreeceSecond Department of Obstetrics and Gynaecology, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreeceUnit of Developmental and Behavioral Pediatrics, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, GreeceSecond Department of Obstetrics and Gynaecology, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreeceDepartment of Obstetrics and Gynecology, Democritus University of Thrace, 691 00 Campus, GreeceSecond Department of Obstetrics and Gynaecology, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, GreecePreeclampsia is a multisystemic clinical syndrome characterized by the appearance of new-onset hypertension and proteinuria or hypertension and end organ dysfunction even without proteinuria after 20 weeks of pregnancy or postpartum. Residing at the severe end of the spectrum of the hypertensive disorders of pregnancy, preeclampsia occurs in 3 to 8% of pregnancies worldwide and is a major cause of maternal and perinatal morbidity and mortality, accounting for 8–10% of all preterm births. The mechanism whereby preeclampsia increases the risk of the neurodevelopmental, cardiovascular, and metabolic morbidity of the mother’s offspring is not well known, but it is possible that the preeclamptic environment induces epigenetic changes that adversely affect developmental plasticity. These developmental changes are crucial for optimal fetal growth and survival but may lead to an increased risk of chronic morbidity in childhood and even later in life. The aim of this review is to summarize both the short- and long-term effects of preeclampsia on offspring based on the current literature.https://www.mdpi.com/2227-9067/10/5/826preeclampsiaoffspringneurodevelopmentfetal cardiac remodelingobesityhigh blood pressure |
| spellingShingle | Sevasti Koulouraki Vasileios Paschos Panagiota Pervanidou Panagiotis Christopoulos Angeliki Gerede Makarios Eleftheriades Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature Children preeclampsia offspring neurodevelopment fetal cardiac remodeling obesity high blood pressure |
| title | Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature |
| title_full | Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature |
| title_fullStr | Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature |
| title_full_unstemmed | Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature |
| title_short | Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature |
| title_sort | short and long term outcomes of preeclampsia in offspring review of the literature |
| topic | preeclampsia offspring neurodevelopment fetal cardiac remodeling obesity high blood pressure |
| url | https://www.mdpi.com/2227-9067/10/5/826 |
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