Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones
ABSTRACT Objective The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers wit...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Brazilian Society of Endocrinology and Metabolism
2019-05-01
|
| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019005003104&lng=en&tlng=en |
| _version_ | 1811337161792815104 |
|---|---|
| author | Canan Yildiz Mustafa Altay Sedat Yildiz Yavuz Çağir Tolga Akkan Yasemin Aydoğan Ünsal Esin Beyan |
| author_facet | Canan Yildiz Mustafa Altay Sedat Yildiz Yavuz Çağir Tolga Akkan Yasemin Aydoğan Ünsal Esin Beyan |
| author_sort | Canan Yildiz |
| collection | DOAJ |
| description | ABSTRACT Objective The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). Subjects and methods A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. Results Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. Conclusion In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients. |
| first_indexed | 2024-04-13T17:50:55Z |
| format | Article |
| id | doaj.art-d89fc1ac69424a9789d3516acf552a2f |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-13T17:50:55Z |
| publishDate | 2019-05-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-d89fc1ac69424a9789d3516acf552a2f2022-12-22T02:36:43ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922019-05-01010.20945/2359-3997000000135S2359-39972019005003104Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormonesCanan YildizMustafa AltaySedat YildizYavuz ÇağirTolga AkkanYasemin Aydoğan ÜnsalEsin BeyanABSTRACT Objective The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). Subjects and methods A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. Results Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. Conclusion In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019005003104&lng=en&tlng=enArterial stiffnessaugmentation indexhyperthyroidismpulse wave analysis |
| spellingShingle | Canan Yildiz Mustafa Altay Sedat Yildiz Yavuz Çağir Tolga Akkan Yasemin Aydoğan Ünsal Esin Beyan Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones Archives of Endocrinology and Metabolism Arterial stiffness augmentation index hyperthyroidism pulse wave analysis |
| title | Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones |
| title_full | Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones |
| title_fullStr | Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones |
| title_full_unstemmed | Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones |
| title_short | Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones |
| title_sort | arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones |
| topic | Arterial stiffness augmentation index hyperthyroidism pulse wave analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019005003104&lng=en&tlng=en |
| work_keys_str_mv | AT cananyildiz arterialstiffnessinhyperthyroidpatientsisdeterioratedduetothyroidhormones AT mustafaaltay arterialstiffnessinhyperthyroidpatientsisdeterioratedduetothyroidhormones AT sedatyildiz arterialstiffnessinhyperthyroidpatientsisdeterioratedduetothyroidhormones AT yavuzcagir arterialstiffnessinhyperthyroidpatientsisdeterioratedduetothyroidhormones AT tolgaakkan arterialstiffnessinhyperthyroidpatientsisdeterioratedduetothyroidhormones AT yaseminaydoganunsal arterialstiffnessinhyperthyroidpatientsisdeterioratedduetothyroidhormones AT esinbeyan arterialstiffnessinhyperthyroidpatientsisdeterioratedduetothyroidhormones |