Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer
Abstract To study the relationships between stromal cell-derived factor-1 (SDF-1ɑ) and renal cell carcinoma (RCC) susceptibility and the presence of single nucleotide polymorphisms in the human X-ray cross-complementary repair gene (XRCC1). Compare SDF-1 based on RCC related data in the TCGA databas...
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-53808-4 |
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| author | Wenjing Zhang Yubo Su Genquan Yue Lingyan Zhao Hailing Li Min Jia Yuqi Wang Dongyang Liu Haisheng Wang Yumin Gao |
| author_facet | Wenjing Zhang Yubo Su Genquan Yue Lingyan Zhao Hailing Li Min Jia Yuqi Wang Dongyang Liu Haisheng Wang Yumin Gao |
| author_sort | Wenjing Zhang |
| collection | DOAJ |
| description | Abstract To study the relationships between stromal cell-derived factor-1 (SDF-1ɑ) and renal cell carcinoma (RCC) susceptibility and the presence of single nucleotide polymorphisms in the human X-ray cross-complementary repair gene (XRCC1). Compare SDF-1 based on RCC related data in the TCGA database α, The expression difference of XRCC1 between RCC tissue and normal tissue; Collect 166 newly diagnosed RCC cases and 166 healthy individuals who underwent physical examinations during the same period, and detect genotype using iMLDR method. The results The rs1801157 locus (C:T) of the SDF-1α gene was not significantly associated with the pathohistological type, the rs1799782 locus (G:A) of the XRCC1 gene was associated with the pathohistological type of RCC, and there were interactions between rs1799782 and smoking, alcohol consumption, pesticide exposure, hair dye, and urine holding. The rs1799782 locus of the XRCC1 gene may be a key factor in the pathogenesis and pathological development of RCC. High SDF-1ɑ expression is a protective factor for the overall survival of patients with RCC, and SDF-1ɑ and XRCC1 may be important for the treatment of RCC. |
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| issn | 2045-2322 |
| language | English |
| last_indexed | 2025-03-22T02:29:07Z |
| publishDate | 2024-02-01 |
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| spelling | doaj.art-d8a0aead3e1b47a5a96350598c21b9ec2024-05-05T11:15:15ZengNature PortfolioScientific Reports2045-23222024-02-0114111210.1038/s41598-024-53808-4Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancerWenjing Zhang0Yubo Su1Genquan Yue2Lingyan Zhao3Hailing Li4Min Jia5Yuqi Wang6Dongyang Liu7Haisheng Wang8Yumin Gao9School of Public Health, Inner Mongolia Medical UniversitySchool of Public Health, Inner Mongolia Medical UniversityDepartment of Urology, Affiliated Hospital of Inner Mongolia Medical UniversitySchool of Public Health, Inner Mongolia Medical UniversitySchool of Public Health, Inner Mongolia Medical UniversitySchool of Public Health, Inner Mongolia Medical UniversitySchool of Public Health, Inner Mongolia Medical UniversitySchool of Public Health, Inner Mongolia Medical UniversitySchool of Public Health, Inner Mongolia Medical UniversitySchool of Public Health, Inner Mongolia Medical UniversityAbstract To study the relationships between stromal cell-derived factor-1 (SDF-1ɑ) and renal cell carcinoma (RCC) susceptibility and the presence of single nucleotide polymorphisms in the human X-ray cross-complementary repair gene (XRCC1). Compare SDF-1 based on RCC related data in the TCGA database α, The expression difference of XRCC1 between RCC tissue and normal tissue; Collect 166 newly diagnosed RCC cases and 166 healthy individuals who underwent physical examinations during the same period, and detect genotype using iMLDR method. The results The rs1801157 locus (C:T) of the SDF-1α gene was not significantly associated with the pathohistological type, the rs1799782 locus (G:A) of the XRCC1 gene was associated with the pathohistological type of RCC, and there were interactions between rs1799782 and smoking, alcohol consumption, pesticide exposure, hair dye, and urine holding. The rs1799782 locus of the XRCC1 gene may be a key factor in the pathogenesis and pathological development of RCC. High SDF-1ɑ expression is a protective factor for the overall survival of patients with RCC, and SDF-1ɑ and XRCC1 may be important for the treatment of RCC.https://doi.org/10.1038/s41598-024-53808-4SDF-1α geneXRCC1 geneSNPRCCBioinformatics analysis |
| spellingShingle | Wenjing Zhang Yubo Su Genquan Yue Lingyan Zhao Hailing Li Min Jia Yuqi Wang Dongyang Liu Haisheng Wang Yumin Gao Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer Scientific Reports SDF-1α gene XRCC1 gene SNP RCC Bioinformatics analysis |
| title | Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer |
| title_full | Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer |
| title_fullStr | Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer |
| title_full_unstemmed | Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer |
| title_short | Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer |
| title_sort | correlations of sdf 1ɑ and xrcc1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of sdf 1α and xrcc1 and the prognosis of renal cancer |
| topic | SDF-1α gene XRCC1 gene SNP RCC Bioinformatics analysis |
| url | https://doi.org/10.1038/s41598-024-53808-4 |
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