Seeing and believing: recent advances in imaging cell-cell interactions [v1; ref status: indexed, http://f1000r.es/5br]
Advances in cell and developmental biology have often been closely linked to advances in our ability to visualize structure and function at many length and time scales. In this review, we discuss how new imaging technologies and new reagents have provided novel insights into the biology of cadherin-...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2015-07-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/4-273/v1 |
| _version_ | 1818501306672742400 |
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| author | Alpha S. Yap Magdalene Michael Robert G. Parton |
| author_facet | Alpha S. Yap Magdalene Michael Robert G. Parton |
| author_sort | Alpha S. Yap |
| collection | DOAJ |
| description | Advances in cell and developmental biology have often been closely linked to advances in our ability to visualize structure and function at many length and time scales. In this review, we discuss how new imaging technologies and new reagents have provided novel insights into the biology of cadherin-based cell-cell junctions. We focus on three developments: the application of super-resolution optical technologies to characterize the nanoscale organization of cadherins at cell-cell contacts, new approaches to interrogate the mechanical forces that act upon junctions, and advances in electron microscopy which have the potential to transform our understanding of cell-cell junctions. |
| first_indexed | 2024-12-10T20:54:21Z |
| format | Article |
| id | doaj.art-d8a17267413847aeb9ecec97d94ff2d4 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-10T20:54:21Z |
| publishDate | 2015-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-d8a17267413847aeb9ecec97d94ff2d42022-12-22T01:34:01ZengF1000 Research LtdF1000Research2046-14022015-07-01410.12688/f1000research.6435.16903Seeing and believing: recent advances in imaging cell-cell interactions [v1; ref status: indexed, http://f1000r.es/5br]Alpha S. Yap0Magdalene Michael1Robert G. Parton2Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, 4072, AustraliaDivision of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, 4072, AustraliaDivision of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, 4072, AustraliaAdvances in cell and developmental biology have often been closely linked to advances in our ability to visualize structure and function at many length and time scales. In this review, we discuss how new imaging technologies and new reagents have provided novel insights into the biology of cadherin-based cell-cell junctions. We focus on three developments: the application of super-resolution optical technologies to characterize the nanoscale organization of cadherins at cell-cell contacts, new approaches to interrogate the mechanical forces that act upon junctions, and advances in electron microscopy which have the potential to transform our understanding of cell-cell junctions.http://f1000research.com/articles/4-273/v1Cell AdhesionCell SignalingChemical Biology of the CellCytoskeletonDevelopmental Molecular MechanismsMembranes & SortingMorphogenesis & Cell Biology |
| spellingShingle | Alpha S. Yap Magdalene Michael Robert G. Parton Seeing and believing: recent advances in imaging cell-cell interactions [v1; ref status: indexed, http://f1000r.es/5br] F1000Research Cell Adhesion Cell Signaling Chemical Biology of the Cell Cytoskeleton Developmental Molecular Mechanisms Membranes & Sorting Morphogenesis & Cell Biology |
| title | Seeing and believing: recent advances in imaging cell-cell interactions [v1; ref status: indexed, http://f1000r.es/5br] |
| title_full | Seeing and believing: recent advances in imaging cell-cell interactions [v1; ref status: indexed, http://f1000r.es/5br] |
| title_fullStr | Seeing and believing: recent advances in imaging cell-cell interactions [v1; ref status: indexed, http://f1000r.es/5br] |
| title_full_unstemmed | Seeing and believing: recent advances in imaging cell-cell interactions [v1; ref status: indexed, http://f1000r.es/5br] |
| title_short | Seeing and believing: recent advances in imaging cell-cell interactions [v1; ref status: indexed, http://f1000r.es/5br] |
| title_sort | seeing and believing recent advances in imaging cell cell interactions v1 ref status indexed http f1000r es 5br |
| topic | Cell Adhesion Cell Signaling Chemical Biology of the Cell Cytoskeleton Developmental Molecular Mechanisms Membranes & Sorting Morphogenesis & Cell Biology |
| url | http://f1000research.com/articles/4-273/v1 |
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