Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI study
Sleep deprivation in youth has garnered international attention in recent years, as correlational studies have demonstrated significant relationships between lack of sleep and detrimental behavioral and academic outcomes. However, no study to date has systematically examined the neurophysiological c...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929317302530 |
| _version_ | 1811312008618835968 |
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| author | Jennifer L. Robinson Stephen A. Erath Rajesh K. Kana Mona El-Sheikh |
| author_facet | Jennifer L. Robinson Stephen A. Erath Rajesh K. Kana Mona El-Sheikh |
| author_sort | Jennifer L. Robinson |
| collection | DOAJ |
| description | Sleep deprivation in youth has garnered international attention in recent years, as correlational studies have demonstrated significant relationships between lack of sleep and detrimental behavioral and academic outcomes. However, no study to date has systematically examined the neurophysiological consequences of a single night of sleep restriction (i.e., 4 h) in adolescents using ultra-high field functional neuroimaging. Much of what we know regarding the neural consequences of sleep deprivation has come from the adult literature, and among those studies, the majority use region of interest (ROI) approaches, thus disregarding the dynamic mechanisms that may subserve the behavioral effects of sleep restriction. Leveraging a crossover within-subjects design, we demonstrate that pivotal brain regions involved in the default mode and limbic regulatory centers have disrupted functioning following a night of restricted sleep compared to a night of “normal sleep”. Specifically, a normal night (i.e., 8 h) of sleep led to increased global and local efficiency of bilateral amygdala, and less efficiency in the posterior cingulate, as measured by graph theory, compared to a night of sleep restriction. Furthermore, aberrant functional connectivity patterns were identified in key fronto-limbic circuitry, suggesting a potential pathophysiological mechanism underlying the widespread effects of sleep deprivation in youth. |
| first_indexed | 2024-04-13T10:28:50Z |
| format | Article |
| id | doaj.art-d8a3655ec3de41cb8d74982f20777b4c |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-04-13T10:28:50Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-d8a3655ec3de41cb8d74982f20777b4c2022-12-22T02:50:15ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072018-06-0131C11010.1016/j.dcn.2018.03.012Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI studyJennifer L. Robinson0Stephen A. Erath1Rajesh K. Kana2Mona El-Sheikh3Department of Psychology, Auburn University, Auburn, AL, 36849, USADepartment of Human Development and Family Studies, Auburn University, Auburn, AL, 36849, USAAlabama Advanced Imaging Consortium, USADepartment of Human Development and Family Studies, Auburn University, Auburn, AL, 36849, USASleep deprivation in youth has garnered international attention in recent years, as correlational studies have demonstrated significant relationships between lack of sleep and detrimental behavioral and academic outcomes. However, no study to date has systematically examined the neurophysiological consequences of a single night of sleep restriction (i.e., 4 h) in adolescents using ultra-high field functional neuroimaging. Much of what we know regarding the neural consequences of sleep deprivation has come from the adult literature, and among those studies, the majority use region of interest (ROI) approaches, thus disregarding the dynamic mechanisms that may subserve the behavioral effects of sleep restriction. Leveraging a crossover within-subjects design, we demonstrate that pivotal brain regions involved in the default mode and limbic regulatory centers have disrupted functioning following a night of restricted sleep compared to a night of “normal sleep”. Specifically, a normal night (i.e., 8 h) of sleep led to increased global and local efficiency of bilateral amygdala, and less efficiency in the posterior cingulate, as measured by graph theory, compared to a night of sleep restriction. Furthermore, aberrant functional connectivity patterns were identified in key fronto-limbic circuitry, suggesting a potential pathophysiological mechanism underlying the widespread effects of sleep deprivation in youth.http://www.sciencedirect.com/science/article/pii/S1878929317302530ActigraphyAdolescenceResting-state fMRISleep restrictionDefault-mode network |
| spellingShingle | Jennifer L. Robinson Stephen A. Erath Rajesh K. Kana Mona El-Sheikh Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI study Developmental Cognitive Neuroscience Actigraphy Adolescence Resting-state fMRI Sleep restriction Default-mode network |
| title | Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI study |
| title_full | Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI study |
| title_fullStr | Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI study |
| title_full_unstemmed | Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI study |
| title_short | Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI study |
| title_sort | neurophysiological differences in the adolescent brain following a single night of restricted sleep a 7t fmri study |
| topic | Actigraphy Adolescence Resting-state fMRI Sleep restriction Default-mode network |
| url | http://www.sciencedirect.com/science/article/pii/S1878929317302530 |
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