Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development
Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics. Methods: In this study, a gene expression profile from a microarray study was selected for more investigation. Results: The study of Down syndrom...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iran University of Medical Sciences
2021-01-01
|
| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/article-1-1384-en.html |
| _version_ | 1797285023305433088 |
|---|---|
| author | Mona Zamanian Azodi Mostafa Rezaei Tavirani Majid Rezaei Tavirani Mohammad Rostami Nejad |
| author_facet | Mona Zamanian Azodi Mostafa Rezaei Tavirani Majid Rezaei Tavirani Mohammad Rostami Nejad |
| author_sort | Mona Zamanian Azodi |
| collection | DOAJ |
| description | Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.
Methods: In this study, a gene expression profile from a microarray study was selected for more investigation.
Results: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties. These genes are introduced as RHOA, FGF2, FYN, and CD44, and their level of expression is high in these patients.
Conclusion: This study suggests that besides chromosomes 21, there are additional contributing chromosomes to the risk of Down syndrome development. Besides, these genes could be used for clinical studies after more analysis. |
| first_indexed | 2024-03-07T17:56:12Z |
| format | Article |
| id | doaj.art-d8a84a38be2f431b8e6370ebf8952782 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:56:12Z |
| publishDate | 2021-01-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-d8a84a38be2f431b8e6370ebf89527822024-03-02T12:15:57ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422021-01-011217988Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome DevelopmentMona Zamanian Azodi0Mostafa Rezaei Tavirani1Majid Rezaei Tavirani2Mohammad Rostami Nejad3 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Research Institute For Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics. Methods: In this study, a gene expression profile from a microarray study was selected for more investigation. Results: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties. These genes are introduced as RHOA, FGF2, FYN, and CD44, and their level of expression is high in these patients. Conclusion: This study suggests that besides chromosomes 21, there are additional contributing chromosomes to the risk of Down syndrome development. Besides, these genes could be used for clinical studies after more analysis.http://bcn.iums.ac.ir/article-1-1384-en.htmldown syndromeprotein interaction mapstranscriptomedifferentially expressed genesbiological process |
| spellingShingle | Mona Zamanian Azodi Mostafa Rezaei Tavirani Majid Rezaei Tavirani Mohammad Rostami Nejad Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development Basic and Clinical Neuroscience down syndrome protein interaction maps transcriptome differentially expressed genes biological process |
| title | Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development |
| title_full | Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development |
| title_fullStr | Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development |
| title_full_unstemmed | Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development |
| title_short | Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development |
| title_sort | bioinformatics investigation and contribution of other chromosomes besides chromosome 21 in the risk of down syndrome development |
| topic | down syndrome protein interaction maps transcriptome differentially expressed genes biological process |
| url | http://bcn.iums.ac.ir/article-1-1384-en.html |
| work_keys_str_mv | AT monazamanianazodi bioinformaticsinvestigationandcontributionofotherchromosomesbesideschromosome21intheriskofdownsyndromedevelopment AT mostafarezaeitavirani bioinformaticsinvestigationandcontributionofotherchromosomesbesideschromosome21intheriskofdownsyndromedevelopment AT majidrezaeitavirani bioinformaticsinvestigationandcontributionofotherchromosomesbesideschromosome21intheriskofdownsyndromedevelopment AT mohammadrostaminejad bioinformaticsinvestigationandcontributionofotherchromosomesbesideschromosome21intheriskofdownsyndromedevelopment |