Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage Repair
Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of different...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-12-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00213/full |
| _version_ | 1828822999522869248 |
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| author | Christopher Fellows Csaba Matta Csaba Matta Roza Zakany Ilyas M Khan Ali Mobasheri Ali Mobasheri Ali Mobasheri Ali Mobasheri |
| author_facet | Christopher Fellows Csaba Matta Csaba Matta Roza Zakany Ilyas M Khan Ali Mobasheri Ali Mobasheri Ali Mobasheri Ali Mobasheri |
| author_sort | Christopher Fellows |
| collection | DOAJ |
| description | Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of differentiating into multiple cell lineages and exerting paracrine effects. Due to their easy isolation, expansion and low immunogenicity, MSCs are an attractive option for regenerative medicine for joint repair. Recent studies have identified several MSC tissue reservoirs including in adipose tissue, bone marrow, cartilage, periosteum and muscle. MSCs isolated from these discrete tissue niches exhibit distinct biological activities, and have enhanced regenerative potentials for different tissue types. Each MSC type has advantages and disadvantages for cartilage repair and their use in a clinical setting is a balance between expediency and effectiveness. In this review we explore the challenges associated with cartilage repair and regeneration using MSC-based cell therapies and provide an overview of phenotype, biological activities and functional properties for each MSC population. This paper also specifically explores the therapeutic potential of each type of MSC, particularly focusing on which cells are capable of producing stratified hyaline-like articular cartilage regeneration. Finally we highlight areas for future investigation. Given that patients present with a variety of problems it is unlikely that cartilage regeneration will be a simple ‘one size fits all’, but more likely an array of solutions that need to applied systematically to achieve regeneration of a biomechanically competent repair tissue. |
| first_indexed | 2024-12-12T13:26:34Z |
| format | Article |
| id | doaj.art-d8a8e7d0d1c642c59574d65435aef004 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-12T13:26:34Z |
| publishDate | 2016-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-d8a8e7d0d1c642c59574d65435aef0042022-12-22T00:23:11ZengFrontiers Media S.A.Frontiers in Genetics1664-80212016-12-01710.3389/fgene.2016.00213234346Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage RepairChristopher Fellows0Csaba Matta1Csaba Matta2Roza Zakany3Ilyas M Khan4Ali Mobasheri5Ali Mobasheri6Ali Mobasheri7Ali Mobasheri8University of SurreyUniversity of SurreyUniversity of DebrecenUniversity of DebrecenSwansea University Medical SchoolUniversity of SurreyArthritis Research UK Centre for Sport, Exercise and OsteoarthritisKing AbdulAziz UniversityKing AbdulAziz UniversityCurrent cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of differentiating into multiple cell lineages and exerting paracrine effects. Due to their easy isolation, expansion and low immunogenicity, MSCs are an attractive option for regenerative medicine for joint repair. Recent studies have identified several MSC tissue reservoirs including in adipose tissue, bone marrow, cartilage, periosteum and muscle. MSCs isolated from these discrete tissue niches exhibit distinct biological activities, and have enhanced regenerative potentials for different tissue types. Each MSC type has advantages and disadvantages for cartilage repair and their use in a clinical setting is a balance between expediency and effectiveness. In this review we explore the challenges associated with cartilage repair and regeneration using MSC-based cell therapies and provide an overview of phenotype, biological activities and functional properties for each MSC population. This paper also specifically explores the therapeutic potential of each type of MSC, particularly focusing on which cells are capable of producing stratified hyaline-like articular cartilage regeneration. Finally we highlight areas for future investigation. Given that patients present with a variety of problems it is unlikely that cartilage regeneration will be a simple ‘one size fits all’, but more likely an array of solutions that need to applied systematically to achieve regeneration of a biomechanically competent repair tissue.http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00213/fullAdipose TissueBone MarrowTissue Engineeringarticular cartilageMesenchymal Stem Cell (MSC)Synovial joint |
| spellingShingle | Christopher Fellows Csaba Matta Csaba Matta Roza Zakany Ilyas M Khan Ali Mobasheri Ali Mobasheri Ali Mobasheri Ali Mobasheri Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage Repair Frontiers in Genetics Adipose Tissue Bone Marrow Tissue Engineering articular cartilage Mesenchymal Stem Cell (MSC) Synovial joint |
| title | Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage Repair |
| title_full | Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage Repair |
| title_fullStr | Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage Repair |
| title_full_unstemmed | Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage Repair |
| title_short | Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage Repair |
| title_sort | adipose bone marrow and synovial joint derived mesenchymal stem cells for cartilage repair |
| topic | Adipose Tissue Bone Marrow Tissue Engineering articular cartilage Mesenchymal Stem Cell (MSC) Synovial joint |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00213/full |
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