Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer’s Disease
Background/Aims: Many patients presenting to a memory disorders clinic for subjective memory complaints do not show objective evidence of decline on neuropsychological data, have nonpathological biomarkers for Alzheimer’s disease, and do not develop a neurodegenerative disorder. Lifestyle variables,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2018-11-01
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| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/493749 |
| _version_ | 1818015182436171776 |
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| author | Anna Miley-Akerstedt Vesna Jelic Kristina Marklund Håkan Walles Torbjörn Åkerstedt Göran Hagman Christin Andersson |
| author_facet | Anna Miley-Akerstedt Vesna Jelic Kristina Marklund Håkan Walles Torbjörn Åkerstedt Göran Hagman Christin Andersson |
| author_sort | Anna Miley-Akerstedt |
| collection | DOAJ |
| description | Background/Aims: Many patients presenting to a memory disorders clinic for subjective memory complaints do not show objective evidence of decline on neuropsychological data, have nonpathological biomarkers for Alzheimer’s disease, and do not develop a neurodegenerative disorder. Lifestyle variables, including subjective sleep problems and stress, are factors known to affect cognition. Little is known about how these factors contribute to patients’ subjective sense of memory decline. Understanding how lifestyle factors are associated with the subjective sense of failing memory that causes patients to seek a formal evaluation is important both for diagnostic workup purposes and for finding appropriate interventions and treatment for these persons, who are not likely in the early stages of a neurodegenerative disease. The current study investigated specific lifestyle variables, such as sleep and stress, to characterize those patients that are unlikely to deteriorate cognitively. Methods: Two hundred nine patients (mean age 58 years) from a university hospital memory disorders clinic were included. Results: Sleep problems and having much to do distinguished those with subjective, but not objective, memory complaints and non-pathological biomarkers for Alzheimer’s disease. Conclusions: Lifestyle factors including sleep and stress are useful in characterizing subjective memory complaints from objective problems. Inclusion of these variables could potentially improve health care utilization efficiency and guide interventions. |
| first_indexed | 2024-04-14T06:54:42Z |
| format | Article |
| id | doaj.art-d8aa9bdf266646e294c5b2b71a3baecf |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-04-14T06:54:42Z |
| publishDate | 2018-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-d8aa9bdf266646e294c5b2b71a3baecf2022-12-22T02:06:56ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642018-11-018343945210.1159/000493749493749Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer’s DiseaseAnna Miley-AkerstedtVesna JelicKristina MarklundHåkan WallesTorbjörn ÅkerstedtGöran HagmanChristin AnderssonBackground/Aims: Many patients presenting to a memory disorders clinic for subjective memory complaints do not show objective evidence of decline on neuropsychological data, have nonpathological biomarkers for Alzheimer’s disease, and do not develop a neurodegenerative disorder. Lifestyle variables, including subjective sleep problems and stress, are factors known to affect cognition. Little is known about how these factors contribute to patients’ subjective sense of memory decline. Understanding how lifestyle factors are associated with the subjective sense of failing memory that causes patients to seek a formal evaluation is important both for diagnostic workup purposes and for finding appropriate interventions and treatment for these persons, who are not likely in the early stages of a neurodegenerative disease. The current study investigated specific lifestyle variables, such as sleep and stress, to characterize those patients that are unlikely to deteriorate cognitively. Methods: Two hundred nine patients (mean age 58 years) from a university hospital memory disorders clinic were included. Results: Sleep problems and having much to do distinguished those with subjective, but not objective, memory complaints and non-pathological biomarkers for Alzheimer’s disease. Conclusions: Lifestyle factors including sleep and stress are useful in characterizing subjective memory complaints from objective problems. Inclusion of these variables could potentially improve health care utilization efficiency and guide interventions.https://www.karger.com/Article/FullText/493749Subjective memory impairmentSubjective cognitive impairmentStressSleepPreclinical dementiaMemory clinicMild cognitive impairmentCognitionNeuropsychologyAB42 |
| spellingShingle | Anna Miley-Akerstedt Vesna Jelic Kristina Marklund Håkan Walles Torbjörn Åkerstedt Göran Hagman Christin Andersson Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer’s Disease Dementia and Geriatric Cognitive Disorders Extra Subjective memory impairment Subjective cognitive impairment Stress Sleep Preclinical dementia Memory clinic Mild cognitive impairment Cognition Neuropsychology AB42 |
| title | Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer’s Disease |
| title_full | Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer’s Disease |
| title_fullStr | Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer’s Disease |
| title_full_unstemmed | Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer’s Disease |
| title_short | Lifestyle Factors Are Important Contributors to Subjective Memory Complaints among Patients without Objective Memory Impairment or Positive Neurochemical Biomarkers for Alzheimer’s Disease |
| title_sort | lifestyle factors are important contributors to subjective memory complaints among patients without objective memory impairment or positive neurochemical biomarkers for alzheimer s disease |
| topic | Subjective memory impairment Subjective cognitive impairment Stress Sleep Preclinical dementia Memory clinic Mild cognitive impairment Cognition Neuropsychology AB42 |
| url | https://www.karger.com/Article/FullText/493749 |
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