Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis

The aim of the article is to study frequency and expressiveness of clinico-morphological and dysbiotic intestinal changes in cirrhosis and to estimate its interrelation with manifestations of hepatic encephalopathy. 146 patients with cirrhosis ages 20 to 70 years have been examined. The cirrhosis ha...

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Main Authors: V.V. Ovsyannikova, I.V. Kozlova
Format: Article
Language:Russian
Published: Saratov State Medical University 2010-06-01
Series:Саратовский научно-медицинский журнал
Subjects:
Online Access:http://www.ssmj.ru/system/files/201002_365_369.pdf
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author V.V. Ovsyannikova
I.V. Kozlova
author_facet V.V. Ovsyannikova
I.V. Kozlova
author_sort V.V. Ovsyannikova
collection DOAJ
description The aim of the article is to study frequency and expressiveness of clinico-morphological and dysbiotic intestinal changes in cirrhosis and to estimate its interrelation with manifestations of hepatic encephalopathy. 146 patients with cirrhosis ages 20 to 70 years have been examined. The cirrhosis has been verified by standard methods. Examina¬tion included colonoscopy and stool specimen. Diagnostics of hepatic encephalopathy was based on clinical and psychometric methods. It is established that symptoms of intestinal dyspepsia often occurred in patients with cirrhosis of classes В and С by Chaild-Pugh. According to the endoscopic examination lesions of mucous membrane of large intestine have been revealed in 82% of patients with liver cirrhosis. Morphological research revealed changes in 100% of patients with cirrhosis. Frequency and expressiveness of changes in mucous membrane of large intestine depended on the degree of cirrhosis decompensation. Changes of biocenosis of large intestine were revealed in 93% of patients with cirrhosis, hepatic encephalopathy was diagnosed in 88% of patients, more frequently hepatic encephalopathy of stage I. The cirrhosis is accompanied by structural and functional changes of intestine that make up additional risk factor of development of hepatic encephalopathy
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spelling doaj.art-d8ab9d8e4b9f49fd85035832e0fca6892022-12-21T20:11:19ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал1995-00392076-25182010-06-0162365369Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosisV.V. OvsyannikovaI.V. KozlovaThe aim of the article is to study frequency and expressiveness of clinico-morphological and dysbiotic intestinal changes in cirrhosis and to estimate its interrelation with manifestations of hepatic encephalopathy. 146 patients with cirrhosis ages 20 to 70 years have been examined. The cirrhosis has been verified by standard methods. Examina¬tion included colonoscopy and stool specimen. Diagnostics of hepatic encephalopathy was based on clinical and psychometric methods. It is established that symptoms of intestinal dyspepsia often occurred in patients with cirrhosis of classes В and С by Chaild-Pugh. According to the endoscopic examination lesions of mucous membrane of large intestine have been revealed in 82% of patients with liver cirrhosis. Morphological research revealed changes in 100% of patients with cirrhosis. Frequency and expressiveness of changes in mucous membrane of large intestine depended on the degree of cirrhosis decompensation. Changes of biocenosis of large intestine were revealed in 93% of patients with cirrhosis, hepatic encephalopathy was diagnosed in 88% of patients, more frequently hepatic encephalopathy of stage I. The cirrhosis is accompanied by structural and functional changes of intestine that make up additional risk factor of development of hepatic encephalopathyhttp://www.ssmj.ru/system/files/201002_365_369.pdfcirrhosisdysbacteriosisencephalopathylarge intestine
spellingShingle V.V. Ovsyannikova
I.V. Kozlova
Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis
Саратовский научно-медицинский журнал
cirrhosis
dysbacteriosis
encephalopathy
large intestine
title Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis
title_full Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis
title_fullStr Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis
title_full_unstemmed Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis
title_short Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis
title_sort clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis
topic cirrhosis
dysbacteriosis
encephalopathy
large intestine
url http://www.ssmj.ru/system/files/201002_365_369.pdf
work_keys_str_mv AT vvovsyannikova clinicodiagnosticvalueoffunctionalmorphologicalchangesofintestineinencephalopathydevelopmentincirrhosis
AT ivkozlova clinicodiagnosticvalueoffunctionalmorphologicalchangesofintestineinencephalopathydevelopmentincirrhosis