The Therapeutic Effect of <em>Acanthopanax senticosus</em> Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters
<i>Acanthopanax senticosus</i> (AS) is a medicinal and food homologous plant with many biological activities. In this research, we generated a brain injury model by <sup>60</sup>Co -γ ray radiation at 4 Gy, and gavaged adult mice with the extract with AS, Acanthopanax sentico...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/3/1106 |
| _version_ | 1797485922046967808 |
|---|---|
| author | Chen Song Sijia Li Fangyuan Duan Mengyao Liu Shan Shan Ting Ju Yingchun Zhang Weihong Lu |
| author_facet | Chen Song Sijia Li Fangyuan Duan Mengyao Liu Shan Shan Ting Ju Yingchun Zhang Weihong Lu |
| author_sort | Chen Song |
| collection | DOAJ |
| description | <i>Acanthopanax senticosus</i> (AS) is a medicinal and food homologous plant with many biological activities. In this research, we generated a brain injury model by <sup>60</sup>Co -γ ray radiation at 4 Gy, and gavaged adult mice with the extract with AS, Acanthopanax senticocus polysaccharides (ASPS), flavones, syringin and eleutheroside E (EE) to explore the therapeutic effect and metabolic characteristics of AS on the brain injury. Behavioral tests and pathological experiments showed that the AS prevented the irradiated mice from learning and memory ability impairment and protected the neurons of irradiated mice. Meanwhile, the functional components of AS increased the antioxidant activity of irradiated mice. Furthermore, we found the changes of neurotransmitters, especially in the EE and syringin groups. Finally, distribution and pharmacokinetic analysis of AS showed that the functional components, especially EE, could exert their therapeutic effects in brain of irradiated mice. This lays a theoretical foundation for the further research on the treatment of radiation-induced brain injury by AS. |
| first_indexed | 2024-03-09T23:26:47Z |
| format | Article |
| id | doaj.art-d8ac450c2c71461aa6bebb9d9b96a652 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:26:47Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d8ac450c2c71461aa6bebb9d9b96a6522023-11-23T17:17:44ZengMDPI AGMolecules1420-30492022-02-01273110610.3390/molecules27031106The Therapeutic Effect of <em>Acanthopanax senticosus</em> Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and NeurotransmittersChen Song0Sijia Li1Fangyuan Duan2Mengyao Liu3Shan Shan4Ting Ju5Yingchun Zhang6Weihong Lu7Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China<i>Acanthopanax senticosus</i> (AS) is a medicinal and food homologous plant with many biological activities. In this research, we generated a brain injury model by <sup>60</sup>Co -γ ray radiation at 4 Gy, and gavaged adult mice with the extract with AS, Acanthopanax senticocus polysaccharides (ASPS), flavones, syringin and eleutheroside E (EE) to explore the therapeutic effect and metabolic characteristics of AS on the brain injury. Behavioral tests and pathological experiments showed that the AS prevented the irradiated mice from learning and memory ability impairment and protected the neurons of irradiated mice. Meanwhile, the functional components of AS increased the antioxidant activity of irradiated mice. Furthermore, we found the changes of neurotransmitters, especially in the EE and syringin groups. Finally, distribution and pharmacokinetic analysis of AS showed that the functional components, especially EE, could exert their therapeutic effects in brain of irradiated mice. This lays a theoretical foundation for the further research on the treatment of radiation-induced brain injury by AS.https://www.mdpi.com/1420-3049/27/3/1106functional components of <i>Acanthopanax senticosus</i>radiationbrain injuryneurotransmitterspharmacokinetic |
| spellingShingle | Chen Song Sijia Li Fangyuan Duan Mengyao Liu Shan Shan Ting Ju Yingchun Zhang Weihong Lu The Therapeutic Effect of <em>Acanthopanax senticosus</em> Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters Molecules functional components of <i>Acanthopanax senticosus</i> radiation brain injury neurotransmitters pharmacokinetic |
| title | The Therapeutic Effect of <em>Acanthopanax senticosus</em> Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters |
| title_full | The Therapeutic Effect of <em>Acanthopanax senticosus</em> Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters |
| title_fullStr | The Therapeutic Effect of <em>Acanthopanax senticosus</em> Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters |
| title_full_unstemmed | The Therapeutic Effect of <em>Acanthopanax senticosus</em> Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters |
| title_short | The Therapeutic Effect of <em>Acanthopanax senticosus</em> Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters |
| title_sort | therapeutic effect of em acanthopanax senticosus em components on radiation induced brain injury based on the pharmacokinetics and neurotransmitters |
| topic | functional components of <i>Acanthopanax senticosus</i> radiation brain injury neurotransmitters pharmacokinetic |
| url | https://www.mdpi.com/1420-3049/27/3/1106 |
| work_keys_str_mv | AT chensong thetherapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT sijiali thetherapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT fangyuanduan thetherapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT mengyaoliu thetherapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT shanshan thetherapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT tingju thetherapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT yingchunzhang thetherapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT weihonglu thetherapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT chensong therapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT sijiali therapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT fangyuanduan therapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT mengyaoliu therapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT shanshan therapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT tingju therapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT yingchunzhang therapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters AT weihonglu therapeuticeffectofemacanthopanaxsenticosusemcomponentsonradiationinducedbraininjurybasedonthepharmacokineticsandneurotransmitters |