Benzyl Isothiocyanate Induces Apoptosis and Inhibits Tumor Growth in Canine Mammary Carcinoma via Downregulation of the Cyclin B1/Cdk1 Pathway

Benzyl Isothiocyanate Induces Apoptosis and Inhibits Tumor Growth in Canine Mammary Carcinoma via Downregulation of the Cyclin B1/Cdk1 Pathway

Background: Canine mammary carcinoma is common in female dogs, and its poor prognosis remains a serious clinical challenge, especially in developing countries. Benzyl isothiocyanate (BITC) has attracted great interest because of its inhibitory effect against tumor activity. However, its effect and t...

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Bibliographic Details
Main Authors: Nan Cheng, Hongxiu Diao, Zhaoyan Lin, Jiafeng Gao, Ying Zhao, Weijiao Zhang, Qi Wang, Jiahao Lin, Di Zhang, Yipeng Jin, Yongping Bao, Degui Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Veterinary Science
Subjects:
BITC
apoptosis
cyclin B1
canine mammary tumor
Cdk1
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2020.580530/full

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