Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers
Purpose: A multi-field optimization (MFO) technique that uses beam-specific spot placement volumes (SPVs) and spot avoidance volumes (SAVs) is introduced for bilateral head and neck (H&N) cancers. These beam-specific volumes are used to guide the optimizer to consistently achieve optimal organ-a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Particle Therapy Co-operative Group
2021-06-01
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| Series: | International Journal of Particle Therapy |
| Subjects: | |
| Online Access: | https://theijpt.org/doi/pdf/10.14338/IJPT-20-00060.1 |
| _version_ | 1797203461987631104 |
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| author | Karla Leach, BS Shikui Tang, PhD Jared Sturgeon, MD, PhD Andrew K. Lee, MD Ryan Grover, MD Parag Sanghvi, MD James Urbanic, MD Chang Chang, PhD |
| author_facet | Karla Leach, BS Shikui Tang, PhD Jared Sturgeon, MD, PhD Andrew K. Lee, MD Ryan Grover, MD Parag Sanghvi, MD James Urbanic, MD Chang Chang, PhD |
| author_sort | Karla Leach, BS |
| collection | DOAJ |
| description | Purpose: A multi-field optimization (MFO) technique that uses beam-specific spot placement volumes (SPVs) and spot avoidance volumes (SAVs) is introduced for bilateral head and neck (H&N) cancers. These beam-specific volumes are used to guide the optimizer to consistently achieve optimal organ-at-risk (OAR) sparing with target coverage and plan robustness.
Materials and Methods: Implementation of this technique using a 4-beam, 5-beam, and variant 5-beam arrangement is discussed. The generation of beam-specific SPVs and SAVs derived from target and OARs are shown. The SPVs for select fields are further partitioned into optimization volumes for uniform dose distributions that resemble those of single-field optimization (SFO). A conventional MFO plan that does not use beam-specific spot placement guidance (MFOcon) and an MFO plan that uses only beam-specific SPV (MFOspv) are compared with current technique (MFOspv/sav), using both simulated scenarios and forward-calculated plans on weekly verification computed tomography (VFCT) scans.
Results: Dose distribution characteristics of the 4-beam, 5-beam, and variant 5-beam technique are demonstrated with discussion on OAR sparing. When comparing the MFOcon, MFOspv, and MFOspv/sav, the MFOspv/sav is shown to have superior OAR sparing in 9 of the 14 OARs examined. It also shows clinical plan robustness when evaluated by using both simulated uncertainty scenarios and forward-calculated weekly VFCTs throughout the 7-week treatment course.
Conclusion: The MFOspv/sav technique is a systematic approach using SPVs and SAVs to guide the optimizer to consistently reach desired OAR dose values and plan robustness. |
| first_indexed | 2024-04-24T08:19:43Z |
| format | Article |
| id | doaj.art-d8b11541d08545abac484c0cdc8ecef1 |
| institution | Directory Open Access Journal |
| issn | 2331-5180 |
| language | English |
| last_indexed | 2024-04-24T08:19:43Z |
| publishDate | 2021-06-01 |
| publisher | Particle Therapy Co-operative Group |
| record_format | Article |
| series | International Journal of Particle Therapy |
| spelling | doaj.art-d8b11541d08545abac484c0cdc8ecef12024-04-17T01:54:53ZengParticle Therapy Co-operative GroupInternational Journal of Particle Therapy2331-51802021-06-0181506110.14338/IJPT-20-00060.1i2331-5180-8-1-50Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck CancersKarla Leach, BS0Shikui Tang, PhD1Jared Sturgeon, MD, PhD2Andrew K. Lee, MD3Ryan Grover, MD4Parag Sanghvi, MD5James Urbanic, MD6Chang Chang, PhD71 California Protons Cancer Therapy Center, San Diego, CA, USA2 Texas Center for Proton Therapy, Irving, TX, USA2 Texas Center for Proton Therapy, Irving, TX, USA2 Texas Center for Proton Therapy, Irving, TX, USA1 California Protons Cancer Therapy Center, San Diego, CA, USA1 California Protons Cancer Therapy Center, San Diego, CA, USA1 California Protons Cancer Therapy Center, San Diego, CA, USA1 California Protons Cancer Therapy Center, San Diego, CA, USAPurpose: A multi-field optimization (MFO) technique that uses beam-specific spot placement volumes (SPVs) and spot avoidance volumes (SAVs) is introduced for bilateral head and neck (H&N) cancers. These beam-specific volumes are used to guide the optimizer to consistently achieve optimal organ-at-risk (OAR) sparing with target coverage and plan robustness. Materials and Methods: Implementation of this technique using a 4-beam, 5-beam, and variant 5-beam arrangement is discussed. The generation of beam-specific SPVs and SAVs derived from target and OARs are shown. The SPVs for select fields are further partitioned into optimization volumes for uniform dose distributions that resemble those of single-field optimization (SFO). A conventional MFO plan that does not use beam-specific spot placement guidance (MFOcon) and an MFO plan that uses only beam-specific SPV (MFOspv) are compared with current technique (MFOspv/sav), using both simulated scenarios and forward-calculated plans on weekly verification computed tomography (VFCT) scans. Results: Dose distribution characteristics of the 4-beam, 5-beam, and variant 5-beam technique are demonstrated with discussion on OAR sparing. When comparing the MFOcon, MFOspv, and MFOspv/sav, the MFOspv/sav is shown to have superior OAR sparing in 9 of the 14 OARs examined. It also shows clinical plan robustness when evaluated by using both simulated uncertainty scenarios and forward-calculated weekly VFCTs throughout the 7-week treatment course. Conclusion: The MFOspv/sav technique is a systematic approach using SPVs and SAVs to guide the optimizer to consistently reach desired OAR dose values and plan robustness.https://theijpt.org/doi/pdf/10.14338/IJPT-20-00060.1proton therapyhead and neck cancerpbsmfobeam-specific spot placement guidance |
| spellingShingle | Karla Leach, BS Shikui Tang, PhD Jared Sturgeon, MD, PhD Andrew K. Lee, MD Ryan Grover, MD Parag Sanghvi, MD James Urbanic, MD Chang Chang, PhD Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers International Journal of Particle Therapy proton therapy head and neck cancer pbs mfo beam-specific spot placement guidance |
| title | Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers |
| title_full | Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers |
| title_fullStr | Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers |
| title_full_unstemmed | Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers |
| title_short | Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers |
| title_sort | beam specific spot guidance and optimization for pbs proton treatment of bilateral head and neck cancers |
| topic | proton therapy head and neck cancer pbs mfo beam-specific spot placement guidance |
| url | https://theijpt.org/doi/pdf/10.14338/IJPT-20-00060.1 |
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