Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3
The standardization and control of «BiVac polio» (live attenuated bivalent oral polio vaccine type 1 and 3) developed by M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of the Russian Academy of Medical Sciences, called for establishment of an industry reference standard (IRS) to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2018-02-01
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| Series: | Биопрепараты: Профилактика, диагностика, лечение |
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| Online Access: | https://www.biopreparations.ru/jour/article/view/91 |
| _version_ | 1797244517069357056 |
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| author | E. V. Karpova A. D. Sangadzhieva T. V. Mamontova O. V. Fadeykina R. A. Volkova K. A. Sarkisyan A. A. Movsesyants |
| author_facet | E. V. Karpova A. D. Sangadzhieva T. V. Mamontova O. V. Fadeykina R. A. Volkova K. A. Sarkisyan A. A. Movsesyants |
| author_sort | E. V. Karpova |
| collection | DOAJ |
| description | The standardization and control of «BiVac polio» (live attenuated bivalent oral polio vaccine type 1 and 3) developed by M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of the Russian Academy of Medical Sciences, called for establishment of an industry reference standard (IRS) to be used in determination of infectious units for each type of the poliovirus in a vaccine dose, according to the requirements of the quality standard. The article gives an account of certification performed for the first batch of a live attenuated bivalent oral polio vaccine type 1 and 3 IRS. The following parameters were tested: Clarity, Colourity, рН, Sterility, Identification, Specific activity, Thermal stability. Identification, Specific activity and Thermal stability of the candidate reference standard were assessed in comparison with the vaccine poliovirus type 1 IRS (IRS 42-28-362-2016) and vaccine poliovirus type 3 IRS (IRS 42-28-372-2015). The IRS certified parameter was found to be: 107.38±0.38 TCID50/ml for type 1 and 106.7±0.48 TCID50/ml for type 3. The IRS was assigned with the number IRS 42-28-434-2016 and a shelf life of 1.5 years. The IRS can be used in specific activity testing of «BiVac polio» commercial batches. |
| first_indexed | 2024-03-08T21:44:29Z |
| format | Article |
| id | doaj.art-d8b154d6f56c4c96a2212015e1d71b52 |
| institution | Directory Open Access Journal |
| issn | 2221-996X 2619-1156 |
| language | Russian |
| last_indexed | 2024-04-24T19:12:16Z |
| publishDate | 2018-02-01 |
| publisher | Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Биопрепараты: Профилактика, диагностика, лечение |
| spelling | doaj.art-d8b154d6f56c4c96a2212015e1d71b522024-03-26T09:10:52ZrusMinistry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Биопрепараты: Профилактика, диагностика, лечение2221-996X2619-11562018-02-0117212212791Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3E. V. Karpova0A. D. Sangadzhieva1T. V. Mamontova2O. V. Fadeykina3R. A. Volkova4K. A. Sarkisyan5A. A. Movsesyants6Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsThe standardization and control of «BiVac polio» (live attenuated bivalent oral polio vaccine type 1 and 3) developed by M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of the Russian Academy of Medical Sciences, called for establishment of an industry reference standard (IRS) to be used in determination of infectious units for each type of the poliovirus in a vaccine dose, according to the requirements of the quality standard. The article gives an account of certification performed for the first batch of a live attenuated bivalent oral polio vaccine type 1 and 3 IRS. The following parameters were tested: Clarity, Colourity, рН, Sterility, Identification, Specific activity, Thermal stability. Identification, Specific activity and Thermal stability of the candidate reference standard were assessed in comparison with the vaccine poliovirus type 1 IRS (IRS 42-28-362-2016) and vaccine poliovirus type 3 IRS (IRS 42-28-372-2015). The IRS certified parameter was found to be: 107.38±0.38 TCID50/ml for type 1 and 106.7±0.48 TCID50/ml for type 3. The IRS was assigned with the number IRS 42-28-434-2016 and a shelf life of 1.5 years. The IRS can be used in specific activity testing of «BiVac polio» commercial batches.https://www.biopreparations.ru/jour/article/view/91вакцина полиомиелитная пероральная, двухвалентная, живая аттенуированная 1, 3 типовотраслевой стандартный образецспецифическая активностьреференс-препаратыхранение вакциныкультура клетокlive attenuated bivalent oral polio vaccine type 1 and 3industry reference standardspecific activityreference medicinesvaccine storagecell culture |
| spellingShingle | E. V. Karpova A. D. Sangadzhieva T. V. Mamontova O. V. Fadeykina R. A. Volkova K. A. Sarkisyan A. A. Movsesyants Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3 Биопрепараты: Профилактика, диагностика, лечение вакцина полиомиелитная пероральная, двухвалентная, живая аттенуированная 1, 3 типов отраслевой стандартный образец специфическая активность референс-препараты хранение вакцины культура клеток live attenuated bivalent oral polio vaccine type 1 and 3 industry reference standard specific activity reference medicines vaccine storage cell culture |
| title | Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3 |
| title_full | Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3 |
| title_fullStr | Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3 |
| title_full_unstemmed | Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3 |
| title_short | Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3 |
| title_sort | certification of the industry reference standard for the specific activity of bivac polio live attenuated bivalent oral polio vaccine type 1 and 3 |
| topic | вакцина полиомиелитная пероральная, двухвалентная, живая аттенуированная 1, 3 типов отраслевой стандартный образец специфическая активность референс-препараты хранение вакцины культура клеток live attenuated bivalent oral polio vaccine type 1 and 3 industry reference standard specific activity reference medicines vaccine storage cell culture |
| url | https://www.biopreparations.ru/jour/article/view/91 |
| work_keys_str_mv | AT evkarpova certificationoftheindustryreferencestandardforthespecificactivityofbivacpolioliveattenuatedbivalentoralpoliovaccinetype1and3 AT adsangadzhieva certificationoftheindustryreferencestandardforthespecificactivityofbivacpolioliveattenuatedbivalentoralpoliovaccinetype1and3 AT tvmamontova certificationoftheindustryreferencestandardforthespecificactivityofbivacpolioliveattenuatedbivalentoralpoliovaccinetype1and3 AT ovfadeykina certificationoftheindustryreferencestandardforthespecificactivityofbivacpolioliveattenuatedbivalentoralpoliovaccinetype1and3 AT ravolkova certificationoftheindustryreferencestandardforthespecificactivityofbivacpolioliveattenuatedbivalentoralpoliovaccinetype1and3 AT kasarkisyan certificationoftheindustryreferencestandardforthespecificactivityofbivacpolioliveattenuatedbivalentoralpoliovaccinetype1and3 AT aamovsesyants certificationoftheindustryreferencestandardforthespecificactivityofbivacpolioliveattenuatedbivalentoralpoliovaccinetype1and3 |