A new mathematical model of bacterial interactions in two-species oral biofilms.

Periodontitis are bacterial inflammatory diseases, where the bacterial biofilms present on the tooth-supporting tissues switch from a healthy state towards a pathogenic state. Among bacterial species involved in the disease, Porphyromonas gingivalis has been shown to induce dysbiosis, and to induce...

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Main Authors: Bénédicte Martin, Zohreh Tamanai-Shacoori, Julie Bronsard, Franck Ginguené, Vincent Meuric, Fabrice Mahé, Martine Bonnaure-Mallet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5333920?pdf=render
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author Bénédicte Martin
Zohreh Tamanai-Shacoori
Julie Bronsard
Franck Ginguené
Vincent Meuric
Fabrice Mahé
Martine Bonnaure-Mallet
author_facet Bénédicte Martin
Zohreh Tamanai-Shacoori
Julie Bronsard
Franck Ginguené
Vincent Meuric
Fabrice Mahé
Martine Bonnaure-Mallet
author_sort Bénédicte Martin
collection DOAJ
description Periodontitis are bacterial inflammatory diseases, where the bacterial biofilms present on the tooth-supporting tissues switch from a healthy state towards a pathogenic state. Among bacterial species involved in the disease, Porphyromonas gingivalis has been shown to induce dysbiosis, and to induce virulence of otherwise healthy bacteria like Streptococcus gordonii. During biofilm development, primary colonizers such as S. gordonii first attach to the surface and allow the subsequent adhesion of periodontal pathogens such as P. gingivalis. Interactions between those two bacteria have been extensively studied during the adhesion step of the biofilm. The aim of the study was to understand interactions of both species during the growing phase of the biofilm, for which little knowledge is available, using a mathematical model. This two-species biofilm model was based on a substrate-dependent growth, implemented with damage parameters, and validated thanks to data obtained on experimental biofilms. Three different hypothesis of interactions were proposed and assayed using this model: independence, competition between both bacteria species, or induction of toxicity by one species for the other species. Adequacy between experimental and simulated biofilms were found with the last hypothetic mathematical model. This new mathematical model of two species bacteria biofilms, dependent on different substrates for growing, can be applied to any bacteria species, environmental conditions, or steps of biofilm development. It will be of great interest for exploring bacterial interactions in biofilm conditions.
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spelling doaj.art-d8b29f84b3714bfea04f992c493680f02022-12-21T22:04:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017315310.1371/journal.pone.0173153A new mathematical model of bacterial interactions in two-species oral biofilms.Bénédicte MartinZohreh Tamanai-ShacooriJulie BronsardFranck GinguenéVincent MeuricFabrice MahéMartine Bonnaure-MalletPeriodontitis are bacterial inflammatory diseases, where the bacterial biofilms present on the tooth-supporting tissues switch from a healthy state towards a pathogenic state. Among bacterial species involved in the disease, Porphyromonas gingivalis has been shown to induce dysbiosis, and to induce virulence of otherwise healthy bacteria like Streptococcus gordonii. During biofilm development, primary colonizers such as S. gordonii first attach to the surface and allow the subsequent adhesion of periodontal pathogens such as P. gingivalis. Interactions between those two bacteria have been extensively studied during the adhesion step of the biofilm. The aim of the study was to understand interactions of both species during the growing phase of the biofilm, for which little knowledge is available, using a mathematical model. This two-species biofilm model was based on a substrate-dependent growth, implemented with damage parameters, and validated thanks to data obtained on experimental biofilms. Three different hypothesis of interactions were proposed and assayed using this model: independence, competition between both bacteria species, or induction of toxicity by one species for the other species. Adequacy between experimental and simulated biofilms were found with the last hypothetic mathematical model. This new mathematical model of two species bacteria biofilms, dependent on different substrates for growing, can be applied to any bacteria species, environmental conditions, or steps of biofilm development. It will be of great interest for exploring bacterial interactions in biofilm conditions.http://europepmc.org/articles/PMC5333920?pdf=render
spellingShingle Bénédicte Martin
Zohreh Tamanai-Shacoori
Julie Bronsard
Franck Ginguené
Vincent Meuric
Fabrice Mahé
Martine Bonnaure-Mallet
A new mathematical model of bacterial interactions in two-species oral biofilms.
PLoS ONE
title A new mathematical model of bacterial interactions in two-species oral biofilms.
title_full A new mathematical model of bacterial interactions in two-species oral biofilms.
title_fullStr A new mathematical model of bacterial interactions in two-species oral biofilms.
title_full_unstemmed A new mathematical model of bacterial interactions in two-species oral biofilms.
title_short A new mathematical model of bacterial interactions in two-species oral biofilms.
title_sort new mathematical model of bacterial interactions in two species oral biofilms
url http://europepmc.org/articles/PMC5333920?pdf=render
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