Avian Metapneumovirus Subgroup C Phosphoprotein Suppresses Type I Interferon Production by Blocking Interferon Regulatory Factor 3 Nuclear Translocation

Avian Metapneumovirus Subgroup C Phosphoprotein Suppresses Type I Interferon Production by Blocking Interferon Regulatory Factor 3 Nuclear Translocation

ABSTRACT Avian metapneumovirus subgroup C (aMPV/C) is an important pathogen that causes upper respiratory symptoms and egg production decline in turkeys and chickens. aMPV/C infection leads to inhibition of the host antiviral immune response. However, our understanding of the molecular mechanisms un...

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Bibliographic Details
Main Authors: Lei Hou, Yongyan Shi, Jinshuo Guo, Tong Sun, Dedong Wang, Xiaoyu Yang, Changzhe Liu, Yongqiu Cui, Ning Zhu, Xinxin Tong, Yang Pan, Xufei Feng, Jianwei Zhou, Jue Liu
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
phosphoprotein
IFN-β production
IRF3
nuclear translocation
avian metapneumovirus subgroup C
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03413-22

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