Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin
Phosphaturic mesenchymal tumor (PMT) is strongly related to tumor-induced osteomalacia (TIO) which brings diverse skeletal events, such as bony deformities, gait disturbance, and multiple bone fractures. Overexpressed fibroblast growth factor 23 by the tumor induces hypophosphatemia leading to the o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/2/1081 |
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| author | Junho Jung Minah Kim So-Woon Kim Joo-Young Ohe |
| author_facet | Junho Jung Minah Kim So-Woon Kim Joo-Young Ohe |
| author_sort | Junho Jung |
| collection | DOAJ |
| description | Phosphaturic mesenchymal tumor (PMT) is strongly related to tumor-induced osteomalacia (TIO) which brings diverse skeletal events, such as bony deformities, gait disturbance, and multiple bone fractures. Overexpressed fibroblast growth factor 23 by the tumor induces hypophosphatemia leading to the oncogenic osteomalacia, a rare paraneoplastic syndrome. PMT occurring in the oral and maxillofacial regions is extremely rare, and this case highlights the need to understand mechanisms by which local lesions can affect systemic conditions, and the importance of a combination of physical examinations, laboratory investigations, and radiologic investigations for a decisive diagnosis. |
| first_indexed | 2024-03-09T13:41:46Z |
| format | Article |
| id | doaj.art-d8b37ba69eea4c3abd9982018e4c1852 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T13:41:46Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-d8b37ba69eea4c3abd9982018e4c18522023-11-30T21:05:56ZengMDPI AGApplied Sciences2076-34172023-01-01132108110.3390/app13021081Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare OriginJunho Jung0Minah Kim1So-Woon Kim2Joo-Young Ohe3Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Pathology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of KoreaPhosphaturic mesenchymal tumor (PMT) is strongly related to tumor-induced osteomalacia (TIO) which brings diverse skeletal events, such as bony deformities, gait disturbance, and multiple bone fractures. Overexpressed fibroblast growth factor 23 by the tumor induces hypophosphatemia leading to the oncogenic osteomalacia, a rare paraneoplastic syndrome. PMT occurring in the oral and maxillofacial regions is extremely rare, and this case highlights the need to understand mechanisms by which local lesions can affect systemic conditions, and the importance of a combination of physical examinations, laboratory investigations, and radiologic investigations for a decisive diagnosis.https://www.mdpi.com/2076-3417/13/2/1081phostphaturic mesenchymal tumorosteomalacia |
| spellingShingle | Junho Jung Minah Kim So-Woon Kim Joo-Young Ohe Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin Applied Sciences phostphaturic mesenchymal tumor osteomalacia |
| title | Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin |
| title_full | Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin |
| title_fullStr | Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin |
| title_full_unstemmed | Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin |
| title_short | Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin |
| title_sort | tumor induced osteomalacia as a result of a phosphaturic mesenchymal tumor detecting rare origin |
| topic | phostphaturic mesenchymal tumor osteomalacia |
| url | https://www.mdpi.com/2076-3417/13/2/1081 |
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