MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors
Mucosal-associated invariant T (MAIT) cells are innate-like T cells present at considerable frequencies in human blood and barrier tissues, armed with an expanding array of effector functions in response to homeostatic perturbations. Analogous to other barrier immune cells, their phenotype and funct...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.584521/full |
| _version_ | 1818648814582497280 |
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| author | Ali Amini Ali Amini Declan Pang Carl-Philipp Hackstein Carl-Philipp Hackstein Paul Klenerman Paul Klenerman |
| author_facet | Ali Amini Ali Amini Declan Pang Carl-Philipp Hackstein Carl-Philipp Hackstein Paul Klenerman Paul Klenerman |
| author_sort | Ali Amini |
| collection | DOAJ |
| description | Mucosal-associated invariant T (MAIT) cells are innate-like T cells present at considerable frequencies in human blood and barrier tissues, armed with an expanding array of effector functions in response to homeostatic perturbations. Analogous to other barrier immune cells, their phenotype and function is driven by crosstalk with host and dynamic environmental factors, most pertinently the microbiome. Given their distribution, they must function in diverse extracellular milieus. Tissue-specific and adapted functions of barrier immune cells are shaped by transcriptional programs and regulated through a blend of local cellular, inflammatory, physiological, and metabolic mediators unique to each microenvironment. This review compares the phenotype and function of MAIT cells with other barrier immune cells, highlighting potential areas for future exploration. Appreciation of MAIT cell biology within tissues is crucial to understanding their niche in health and disease. |
| first_indexed | 2024-12-17T01:24:25Z |
| format | Article |
| id | doaj.art-d8b729c994f44eec88696026a57daf08 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T01:24:25Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d8b729c994f44eec88696026a57daf082022-12-21T22:08:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.584521584521MAIT Cells in Barrier Tissues: Lessons from Immediate NeighborsAli Amini0Ali Amini1Declan Pang2Carl-Philipp Hackstein3Carl-Philipp Hackstein4Paul Klenerman5Paul Klenerman6Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomPeter Medawar Building for Pathogen Research, University of Oxford, Oxford, United KingdomPeter Medawar Building for Pathogen Research, University of Oxford, Oxford, United KingdomTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomPeter Medawar Building for Pathogen Research, University of Oxford, Oxford, United KingdomTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomPeter Medawar Building for Pathogen Research, University of Oxford, Oxford, United KingdomMucosal-associated invariant T (MAIT) cells are innate-like T cells present at considerable frequencies in human blood and barrier tissues, armed with an expanding array of effector functions in response to homeostatic perturbations. Analogous to other barrier immune cells, their phenotype and function is driven by crosstalk with host and dynamic environmental factors, most pertinently the microbiome. Given their distribution, they must function in diverse extracellular milieus. Tissue-specific and adapted functions of barrier immune cells are shaped by transcriptional programs and regulated through a blend of local cellular, inflammatory, physiological, and metabolic mediators unique to each microenvironment. This review compares the phenotype and function of MAIT cells with other barrier immune cells, highlighting potential areas for future exploration. Appreciation of MAIT cell biology within tissues is crucial to understanding their niche in health and disease.https://www.frontiersin.org/articles/10.3389/fimmu.2020.584521/fullmucosal-associated invariant T cellsmicroenvironmentmicrobiomemetabolismtissue resident cellsmucosal immunology |
| spellingShingle | Ali Amini Ali Amini Declan Pang Carl-Philipp Hackstein Carl-Philipp Hackstein Paul Klenerman Paul Klenerman MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors Frontiers in Immunology mucosal-associated invariant T cells microenvironment microbiome metabolism tissue resident cells mucosal immunology |
| title | MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors |
| title_full | MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors |
| title_fullStr | MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors |
| title_full_unstemmed | MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors |
| title_short | MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors |
| title_sort | mait cells in barrier tissues lessons from immediate neighbors |
| topic | mucosal-associated invariant T cells microenvironment microbiome metabolism tissue resident cells mucosal immunology |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.584521/full |
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