GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance
Phase separated, membrane-less germ granules preserve fertility and cellular function in animal germ cells. Here the authors show that loss of germ granules impacts piRNA pathway fidelity in the recognition of self and non-self nucleic acids.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32880-2 |
| _version_ | 1828178314999627776 |
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| author | Wenjun Chen Jordan S. Brown Tao He Wei-Sheng Wu Shikui Tu Zhiping Weng Donglei Zhang Heng-Chi Lee |
| author_facet | Wenjun Chen Jordan S. Brown Tao He Wei-Sheng Wu Shikui Tu Zhiping Weng Donglei Zhang Heng-Chi Lee |
| author_sort | Wenjun Chen |
| collection | DOAJ |
| description | Phase separated, membrane-less germ granules preserve fertility and cellular function in animal germ cells. Here the authors show that loss of germ granules impacts piRNA pathway fidelity in the recognition of self and non-self nucleic acids. |
| first_indexed | 2024-04-12T05:14:15Z |
| format | Article |
| id | doaj.art-d8b863c6d92b413c8d5717dec515c6bb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T05:14:15Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d8b863c6d92b413c8d5717dec515c6bb2022-12-22T03:46:41ZengNature PortfolioNature Communications2041-17232022-09-0113111410.1038/s41467-022-32880-2GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillanceWenjun Chen0Jordan S. Brown1Tao He2Wei-Sheng Wu3Shikui Tu4Zhiping Weng5Donglei Zhang6Heng-Chi Lee7Department of Molecular Genetics and Cell Biology, University of ChicagoDepartment of Molecular Genetics and Cell Biology, University of ChicagoCell Architecture Research Institute, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Electrical Engineering, National Cheng Kung UniversityDepartment of Computer Science and Engineering, Shanghai Jiao Tong UniversityDepartment of Biochemistry and Molecular Biotechnology, University of Mass. Chan Medical SchoolCell Architecture Research Institute, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Molecular Genetics and Cell Biology, University of ChicagoPhase separated, membrane-less germ granules preserve fertility and cellular function in animal germ cells. Here the authors show that loss of germ granules impacts piRNA pathway fidelity in the recognition of self and non-self nucleic acids.https://doi.org/10.1038/s41467-022-32880-2 |
| spellingShingle | Wenjun Chen Jordan S. Brown Tao He Wei-Sheng Wu Shikui Tu Zhiping Weng Donglei Zhang Heng-Chi Lee GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance Nature Communications |
| title | GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance |
| title_full | GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance |
| title_fullStr | GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance |
| title_full_unstemmed | GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance |
| title_short | GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance |
| title_sort | glh vasa helicases promote germ granule formation to ensure the fidelity of pirna mediated transcriptome surveillance |
| url | https://doi.org/10.1038/s41467-022-32880-2 |
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