Oncogenic context shapes the fitness landscape of tumor suppression

Oncogenic context shapes the fitness landscape of tumor suppression

Abstract Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain poorly resolved and cannot be revealed by human canc...

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Podrobná bibliografie
Hlavní autoři: Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2023-10-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-023-42156-y

Internet

https://doi.org/10.1038/s41467-023-42156-y

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