Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review
The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Shahid Sadoughi University of Medical Sciences
2023-12-01
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| Series: | Iranian Journal of Diabetes and Obesity |
| Subjects: | |
| Online Access: | http://ijdo.ssu.ac.ir/article-1-835-en.pdf |
| _version_ | 1797364118360948736 |
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| author | Sachini M Thennakoon Niroshima D Withanage |
| author_facet | Sachini M Thennakoon Niroshima D Withanage |
| author_sort | Sachini M Thennakoon |
| collection | DOAJ |
| description | The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes mellitus, suggesting GGT as a risk predictor of T2DM. The incidence of type 2 diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics. |
| first_indexed | 2024-03-08T16:30:40Z |
| format | Article |
| id | doaj.art-d8bbec3103b34126a33d2f95ea95504f |
| institution | Directory Open Access Journal |
| issn | 2008-6792 2345-2250 |
| language | English |
| last_indexed | 2024-03-08T16:30:40Z |
| publishDate | 2023-12-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Diabetes and Obesity |
| spelling | doaj.art-d8bbec3103b34126a33d2f95ea95504f2024-01-06T09:17:34ZengShahid Sadoughi University of Medical SciencesIranian Journal of Diabetes and Obesity2008-67922345-22502023-12-01154243255Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A ReviewSachini M Thennakoon0Niroshima D Withanage1 Department of Biomedical Sciences, Faculty of Science, NSBM Green University, Mahenwatta, Pitipana, Homagama (10206), Sri Lanka Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. The relationship between gamma-glutamyl transferase (GGT) levels and risk factors for type 2 diabetes mellitus (T2DM) and the risk of incident T2DM was assessed using a narrative review of available evidence. Higher circulating levels of GGT are associated with an increased risk of type 2 diabetes mellitus, suggesting GGT as a risk predictor of T2DM. The incidence of type 2 diabetes and its association with GGT elevation could be explained by oxidative stress in cells followed by subclinical inflammation and fatty liver, leading to impaired insulin secretion and insulin resistance. A strong correlation is evident between BMI and GGT, in which hepatic steatosis and insulin resistance are proposed to be the intermediate connecting characteristics.http://ijdo.ssu.ac.ir/article-1-835-en.pdfgamma-glutamyl transferasetype 2 diabetes mellitusbody mass index |
| spellingShingle | Sachini M Thennakoon Niroshima D Withanage Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review Iranian Journal of Diabetes and Obesity gamma-glutamyl transferase type 2 diabetes mellitus body mass index |
| title | Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review |
| title_full | Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review |
| title_fullStr | Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review |
| title_full_unstemmed | Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review |
| title_short | Gamma-Glutamyl Transferase and the Risk of Type 2 Diabetes Mellitus: A Review |
| title_sort | gamma glutamyl transferase and the risk of type 2 diabetes mellitus a review |
| topic | gamma-glutamyl transferase type 2 diabetes mellitus body mass index |
| url | http://ijdo.ssu.ac.ir/article-1-835-en.pdf |
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