Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex
Abstract Conscious perception of limb movements depends on proprioceptive neural responses in the somatosensory cortex. In contrast to tactile sensations, proprioceptive cortical coding is barely studied in the mammalian brain and practically non-existent in rodent research. To understand the cortic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37575-w |
| _version_ | 1797845907551551488 |
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| author | Ignacio Alonso Irina Scheer Mélanie Palacio-Manzano Noémie Frézel-Jacob Antoine Philippides Mario Prsa |
| author_facet | Ignacio Alonso Irina Scheer Mélanie Palacio-Manzano Noémie Frézel-Jacob Antoine Philippides Mario Prsa |
| author_sort | Ignacio Alonso |
| collection | DOAJ |
| description | Abstract Conscious perception of limb movements depends on proprioceptive neural responses in the somatosensory cortex. In contrast to tactile sensations, proprioceptive cortical coding is barely studied in the mammalian brain and practically non-existent in rodent research. To understand the cortical representation of this important sensory modality we developed a passive forelimb displacement paradigm in behaving mice and also trained them to perceptually discriminate where their limb is moved in space. We delineated the rodent proprioceptive cortex with wide-field calcium imaging and optogenetic silencing experiments during behavior. Our results reveal that proprioception is represented in both sensory and motor cortical areas. In addition, behavioral measurements and responses of layer 2/3 neurons imaged with two-photon microscopy reveal that passive limb movements are both perceived and encoded in the mouse cortex as a spatial direction vector that interfaces the limb with the body’s peripersonal space. |
| first_indexed | 2024-04-09T17:46:33Z |
| format | Article |
| id | doaj.art-d8bd3f1f59334a0ca8680664692afdca |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T17:46:33Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d8bd3f1f59334a0ca8680664692afdca2023-04-16T11:19:08ZengNature PortfolioNature Communications2041-17232023-04-0114111610.1038/s41467-023-37575-wPeripersonal encoding of forelimb proprioception in the mouse somatosensory cortexIgnacio Alonso0Irina Scheer1Mélanie Palacio-Manzano2Noémie Frézel-Jacob3Antoine Philippides4Mario Prsa5Department of Neuroscience and Movement Science, University of FribourgDepartment of Neuroscience and Movement Science, University of FribourgDepartment of Neuroscience and Movement Science, University of FribourgDepartment of Neuroscience and Movement Science, University of FribourgDepartment of Basic Neurosciences, University of GenevaDepartment of Neuroscience and Movement Science, University of FribourgAbstract Conscious perception of limb movements depends on proprioceptive neural responses in the somatosensory cortex. In contrast to tactile sensations, proprioceptive cortical coding is barely studied in the mammalian brain and practically non-existent in rodent research. To understand the cortical representation of this important sensory modality we developed a passive forelimb displacement paradigm in behaving mice and also trained them to perceptually discriminate where their limb is moved in space. We delineated the rodent proprioceptive cortex with wide-field calcium imaging and optogenetic silencing experiments during behavior. Our results reveal that proprioception is represented in both sensory and motor cortical areas. In addition, behavioral measurements and responses of layer 2/3 neurons imaged with two-photon microscopy reveal that passive limb movements are both perceived and encoded in the mouse cortex as a spatial direction vector that interfaces the limb with the body’s peripersonal space.https://doi.org/10.1038/s41467-023-37575-w |
| spellingShingle | Ignacio Alonso Irina Scheer Mélanie Palacio-Manzano Noémie Frézel-Jacob Antoine Philippides Mario Prsa Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex Nature Communications |
| title | Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex |
| title_full | Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex |
| title_fullStr | Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex |
| title_full_unstemmed | Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex |
| title_short | Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex |
| title_sort | peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex |
| url | https://doi.org/10.1038/s41467-023-37575-w |
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