LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure

LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure

Abstract Background Osteoporosis is a degenerative disease characterized by reduced bone mass, with low peak bone mass being the predominant manifestation during development and having an intrauterine origin. Pregnant women at risk of preterm delivery are commonly treated with dexamethasone to promo...

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Bibliographic Details
Main Authors: Tao Jiang, Hao Xiao, Bin Li, Hangyuan He, Hui Wang, Liaobin Chen
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cell Communication and Signaling
Subjects:
Dexamethasone
Osteoclast
Low peak bone mass
Reactive oxygen species
Lysyl oxidase
Intrauterine programming
Online Access:https://doi.org/10.1186/s12964-023-01115-2

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