Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study
Transcranial magnetic stimulation (TMS) was used to test the functional role of parietal and prefrontal cortical regions activated during a playing card Guilty Knowledge Task (GKT). Single-pulse TMS was applied to 15 healthy volunteers at each of three target sites: left and right dorsolateral prefr...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.883337/full |
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| author | Bruce Luber Lysianne Beynel Timothy Spellman Hannah Gura Markus Ploesser Markus Ploesser Kate Termini Sarah H. Lisanby |
| author_facet | Bruce Luber Lysianne Beynel Timothy Spellman Hannah Gura Markus Ploesser Markus Ploesser Kate Termini Sarah H. Lisanby |
| author_sort | Bruce Luber |
| collection | DOAJ |
| description | Transcranial magnetic stimulation (TMS) was used to test the functional role of parietal and prefrontal cortical regions activated during a playing card Guilty Knowledge Task (GKT). Single-pulse TMS was applied to 15 healthy volunteers at each of three target sites: left and right dorsolateral prefrontal cortex and midline parietal cortex. TMS pulses were applied at each of five latencies (from 0 to 480 ms) after the onset of a card stimulus. TMS applied to the parietal cortex exerted a latency-specific increase in inverse efficiency score and in reaction time when subjects were instructed to lie relative to when asked to respond with the truth, and this effect was specific to when TMS was applied at 240 ms after stimulus onset. No effects of TMS were detected at left or right DLPFC sites. This manipulation with TMS of performance in a deception task appears to support a critical role for the parietal cortex in intentional false responding, particularly in stimulus selection processes needed to execute a deceptive response in the context of a GKT. However, this interpretation is only preliminary, as further experiments are needed to compare performance within and outside of a deceptive context to clarify the effects of deceptive intent. |
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| format | Article |
| id | doaj.art-d8c3851867184b84a36854f5ef6af38f |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-13T19:05:13Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-d8c3851867184b84a36854f5ef6af38f2022-12-22T02:34:00ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-06-011610.3389/fnhum.2022.883337883337Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary StudyBruce Luber0Lysianne Beynel1Timothy Spellman2Hannah Gura3Markus Ploesser4Markus Ploesser5Kate Termini6Sarah H. Lisanby7Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, United StatesNoninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, United StatesDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, United StatesNoninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, United StatesDepartment of Psychiatry and Neurosciences, University of California, Riverside, Riverside, CA, United StatesForensic Psychiatry, Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, CanadaClinical and Forensic Psychology, Fifth Avenue Forensics, New York, NY, United StatesNoninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, United StatesTranscranial magnetic stimulation (TMS) was used to test the functional role of parietal and prefrontal cortical regions activated during a playing card Guilty Knowledge Task (GKT). Single-pulse TMS was applied to 15 healthy volunteers at each of three target sites: left and right dorsolateral prefrontal cortex and midline parietal cortex. TMS pulses were applied at each of five latencies (from 0 to 480 ms) after the onset of a card stimulus. TMS applied to the parietal cortex exerted a latency-specific increase in inverse efficiency score and in reaction time when subjects were instructed to lie relative to when asked to respond with the truth, and this effect was specific to when TMS was applied at 240 ms after stimulus onset. No effects of TMS were detected at left or right DLPFC sites. This manipulation with TMS of performance in a deception task appears to support a critical role for the parietal cortex in intentional false responding, particularly in stimulus selection processes needed to execute a deceptive response in the context of a GKT. However, this interpretation is only preliminary, as further experiments are needed to compare performance within and outside of a deceptive context to clarify the effects of deceptive intent.https://www.frontiersin.org/articles/10.3389/fnhum.2022.883337/fullTMSdeceptionparietal cortexfronto-parietal networkguilty knowledge task (GKT) |
| spellingShingle | Bruce Luber Lysianne Beynel Timothy Spellman Hannah Gura Markus Ploesser Markus Ploesser Kate Termini Sarah H. Lisanby Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study Frontiers in Human Neuroscience TMS deception parietal cortex fronto-parietal network guilty knowledge task (GKT) |
| title | Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study |
| title_full | Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study |
| title_fullStr | Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study |
| title_full_unstemmed | Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study |
| title_short | Effects of Online Single Pulse Transcranial Magnetic Stimulation on Prefrontal and Parietal Cortices in Deceptive Processing: A Preliminary Study |
| title_sort | effects of online single pulse transcranial magnetic stimulation on prefrontal and parietal cortices in deceptive processing a preliminary study |
| topic | TMS deception parietal cortex fronto-parietal network guilty knowledge task (GKT) |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.883337/full |
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