Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling
Bone adaptation occurs as a response to external loadings and involves bone resorption by osteoclasts followed by the formation of new bone by osteoblasts. It is directly triggered by the transduction phase by osteocytes embedded within the bone matrix. The bone remodeling process is governed by the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2014.00006/full |
| _version_ | 1818837770501619712 |
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| author | Ridha eHambli Ridha eHambli |
| author_facet | Ridha eHambli Ridha eHambli |
| author_sort | Ridha eHambli |
| collection | DOAJ |
| description | Bone adaptation occurs as a response to external loadings and involves bone resorption by osteoclasts followed by the formation of new bone by osteoblasts. It is directly triggered by the transduction phase by osteocytes embedded within the bone matrix. The bone remodeling process is governed by the interactions between osteoblasts and osteoclasts through the expression of several autocrine and paracrine factors that control bone cell populations and their relative rate of differentiation and proliferation. A review of the literature shows that despite the progress in bone remodeling simulation using the finite element method, there is still a lack of predictive models that explicitly consider the interaction between osteoblasts and osteoclasts combined with the mechanical response of bone. The current study attempts to develop a finite element model to describe the bone remodeling process, taking into consideration the activities of osteoclasts and osteoblasts. The mechanical behaviour of bone is described by taking into account the bone material fatigue damage accumulation and mineralization. A coupled strain-damage stimulus function is proposed which controls the level of autocrine and paracrine factors. The cellular behaviour is based on Komarova et al.’s dynamic law (2003) which describes the autocrine and paracrine interactions between osteoblasts and osteoclasts and computes cell population dynamics and changes in bone mass at a discrete site of bone remodeling. Therefore, when an external mechanical stress is applied, bone formation and resorption is governed by cells dynamic rather than adaptative elasticity approaches. The proposed finite element model has been implemented in the finite element code Abaqus (UMAT routine). An example of human proximal femur is investigated using the model developed. The model was able to predict final human proximal femur adaptation similar to the patterns observed in a human proximal femur. |
| first_indexed | 2024-12-19T03:27:47Z |
| format | Article |
| id | doaj.art-d8c3daa8b14b425c9a4e480fe3234f82 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-19T03:27:47Z |
| publishDate | 2014-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d8c3daa8b14b425c9a4e480fe3234f822022-12-21T20:37:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852014-04-01210.3389/fbioe.2014.0000669988Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modelingRidha eHambli0Ridha eHambli1I3MTOPolytechnique OrleansBone adaptation occurs as a response to external loadings and involves bone resorption by osteoclasts followed by the formation of new bone by osteoblasts. It is directly triggered by the transduction phase by osteocytes embedded within the bone matrix. The bone remodeling process is governed by the interactions between osteoblasts and osteoclasts through the expression of several autocrine and paracrine factors that control bone cell populations and their relative rate of differentiation and proliferation. A review of the literature shows that despite the progress in bone remodeling simulation using the finite element method, there is still a lack of predictive models that explicitly consider the interaction between osteoblasts and osteoclasts combined with the mechanical response of bone. The current study attempts to develop a finite element model to describe the bone remodeling process, taking into consideration the activities of osteoclasts and osteoblasts. The mechanical behaviour of bone is described by taking into account the bone material fatigue damage accumulation and mineralization. A coupled strain-damage stimulus function is proposed which controls the level of autocrine and paracrine factors. The cellular behaviour is based on Komarova et al.’s dynamic law (2003) which describes the autocrine and paracrine interactions between osteoblasts and osteoclasts and computes cell population dynamics and changes in bone mass at a discrete site of bone remodeling. Therefore, when an external mechanical stress is applied, bone formation and resorption is governed by cells dynamic rather than adaptative elasticity approaches. The proposed finite element model has been implemented in the finite element code Abaqus (UMAT routine). An example of human proximal femur is investigated using the model developed. The model was able to predict final human proximal femur adaptation similar to the patterns observed in a human proximal femur.http://journal.frontiersin.org/Journal/10.3389/fbioe.2014.00006/fullBone RemodelingFinite ElementMechanical stimulusBasic Multicellular UnitProximal femur |
| spellingShingle | Ridha eHambli Ridha eHambli Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling Frontiers in Bioengineering and Biotechnology Bone Remodeling Finite Element Mechanical stimulus Basic Multicellular Unit Proximal femur |
| title | Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling |
| title_full | Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling |
| title_fullStr | Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling |
| title_full_unstemmed | Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling |
| title_short | Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling |
| title_sort | connecting mechanics and bone cell activities in the bone remodeling process an integrated finite element modeling |
| topic | Bone Remodeling Finite Element Mechanical stimulus Basic Multicellular Unit Proximal femur |
| url | http://journal.frontiersin.org/Journal/10.3389/fbioe.2014.00006/full |
| work_keys_str_mv | AT ridhaehambli connectingmechanicsandbonecellactivitiesintheboneremodelingprocessanintegratedfiniteelementmodeling AT ridhaehambli connectingmechanicsandbonecellactivitiesintheboneremodelingprocessanintegratedfiniteelementmodeling |