Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing
Wound healing is a highly orchestrated biological process characterized by sequential phases involving inflammation, proliferation, and tissue remodeling, and the role of endogenous electrical signals in regulating these phases has been highlighted. Recently, external electrostimulation has been sho...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Biomimetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-7673/8/7/517 |
| _version_ | 1797460078277689344 |
|---|---|
| author | Hye-Jeong Jang Daniel Manaye Tiruneh Hanjun Ryu Jeong-Kee Yoon |
| author_facet | Hye-Jeong Jang Daniel Manaye Tiruneh Hanjun Ryu Jeong-Kee Yoon |
| author_sort | Hye-Jeong Jang |
| collection | DOAJ |
| description | Wound healing is a highly orchestrated biological process characterized by sequential phases involving inflammation, proliferation, and tissue remodeling, and the role of endogenous electrical signals in regulating these phases has been highlighted. Recently, external electrostimulation has been shown to enhance these processes by promoting cell migration, extracellular matrix formation, and growth factor release while suppressing pro-inflammatory signals and reducing the risk of infection. Among the innovative approaches, piezoelectric and triboelectric nanogenerators have emerged as the next generation of flexible and wireless electronics designed for energy harvesting and efficiently converting mechanical energy into electrical power. In this review, we discuss recent advances in the emerging field of nanogenerators for harnessing electrical stimulation to accelerate wound healing. We elucidate the fundamental mechanisms of wound healing and relevant bioelectric physiology, as well as the principles underlying each nanogenerator technology, and review their preclinical applications. In addition, we address the prominent challenges and outline the future prospects for this emerging era of electrical wound-healing devices. |
| first_indexed | 2024-03-09T16:59:47Z |
| format | Article |
| id | doaj.art-d8c405c3167a439a8231c484c85a6cfc |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-03-09T16:59:47Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-d8c405c3167a439a8231c484c85a6cfc2023-11-24T14:31:34ZengMDPI AGBiomimetics2313-76732023-11-018751710.3390/biomimetics8070517Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound HealingHye-Jeong Jang0Daniel Manaye Tiruneh1Hanjun Ryu2Jeong-Kee Yoon3Department of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaDepartment of Intelligence Energy and Industry, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of Intelligence Energy and Industry, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong-si 17546, Gyeonggi-do, Republic of KoreaWound healing is a highly orchestrated biological process characterized by sequential phases involving inflammation, proliferation, and tissue remodeling, and the role of endogenous electrical signals in regulating these phases has been highlighted. Recently, external electrostimulation has been shown to enhance these processes by promoting cell migration, extracellular matrix formation, and growth factor release while suppressing pro-inflammatory signals and reducing the risk of infection. Among the innovative approaches, piezoelectric and triboelectric nanogenerators have emerged as the next generation of flexible and wireless electronics designed for energy harvesting and efficiently converting mechanical energy into electrical power. In this review, we discuss recent advances in the emerging field of nanogenerators for harnessing electrical stimulation to accelerate wound healing. We elucidate the fundamental mechanisms of wound healing and relevant bioelectric physiology, as well as the principles underlying each nanogenerator technology, and review their preclinical applications. In addition, we address the prominent challenges and outline the future prospects for this emerging era of electrical wound-healing devices.https://www.mdpi.com/2313-7673/8/7/517nanogeneratorpiezoelectrictriboelectricwound healing |
| spellingShingle | Hye-Jeong Jang Daniel Manaye Tiruneh Hanjun Ryu Jeong-Kee Yoon Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing Biomimetics nanogenerator piezoelectric triboelectric wound healing |
| title | Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing |
| title_full | Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing |
| title_fullStr | Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing |
| title_full_unstemmed | Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing |
| title_short | Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing |
| title_sort | piezoelectric and triboelectric nanogenerators for enhanced wound healing |
| topic | nanogenerator piezoelectric triboelectric wound healing |
| url | https://www.mdpi.com/2313-7673/8/7/517 |
| work_keys_str_mv | AT hyejeongjang piezoelectricandtriboelectricnanogeneratorsforenhancedwoundhealing AT danielmanayetiruneh piezoelectricandtriboelectricnanogeneratorsforenhancedwoundhealing AT hanjunryu piezoelectricandtriboelectricnanogeneratorsforenhancedwoundhealing AT jeongkeeyoon piezoelectricandtriboelectricnanogeneratorsforenhancedwoundhealing |